近年来,越来越多的研究证实,巨噬细胞在人体多种组织器官再生过程中发挥重要作用。在骨骼肌再生过程中,巨噬细胞的参与是必需的。骨骼肌受损后,成肌细胞与固有巨噬细胞募集循环系统中的单核/巨噬细胞;浸润的巨噬细胞吞噬凋亡或坏死的肌纤维后,从致炎的表型转变为抗炎表型;抗炎巨噬细胞分泌的因子促进了成肌细胞的分化和融合,从而介导了骨骼肌的再生。

In recent years, many researches have demonstrated that macrophages play a vital role in organ or tissue regeneration. Macrophages are necessary for skeletal muscle regeneration after injury. The recruitment of circulating mono-cytes/macrophages was mediated through myogenic cells and muscle resident macrophages. Macrophages are involved in both phases of skeletal muscle regeneration: first, swallowing necrotic myo-fibers, then the phenotype of macrophages switched from pro-inflammatory to anti-inflammatory. Second, factors secreted by anti-inflammatory macrophages improved the differentiation of myogenic cells and resulted in regeneration of skeletal muscle.