自1970年发明了第一个人工骨替代品-PMMA,研究人员进行了大量的临床研究。现如今,PMMA已经广泛应用于临床治疗骨髓炎。临床治疗结果及研究结果表明,PMMA在治疗骨髓炎和降低病死率上起了很大的作用。根据材料的降解性质,载药系统常常可以分为生物降解性材料和不可降解性材料。两种载药系统作为人工骨材料都需要在药物释放上达到局部最小抑菌浓度。本文将就载药系统类型、制作方法、载药系统性质、药物释放动力学进行综述。

In 1970,the first bone substitute-PMMA was created and a lot of clinical studies were conducted.Clinical applications demonstrate good results and the mortality rate of osteomyelitis is significantly reduced.According to the degradation of materials,the drug-delivery system can be divided into biodegradable materials and non-degradable materials.As the bone substitute,the two types of materials were required to achieve the minimum inhibitory concentration in nature.The system types,preparation methods,the nature of the drug,and the drug release kinetics were reviewed.