目的探讨人脐带间充质干细胞移植治疗晚期外伤性癫痫的临床价值。方法对31例晚期外伤性癫痫患者进行人脐带间充质干细胞移植,观察临床效果。结果癫痫发作完全消失或仅有先兆者21例,极少发作(≤3次/年)者5例,发作明显改善(减少≥75%)者4例,无明显改善(减少<75%)者1例,满意率83.87%。结论人脐带间充质干细胞移植对治疗外伤性癫痫具有较好的效果。

Objective To explore the clinical efficacy of human umbilical cord mesenchymal stem cells transplantation in the treatment of late traumatic epilepsy.Methods Thirty-one patients with late traumatic epilepsy were transplanted with human umbilical cord mesenchymal stem cells and the clinical effect was observed.Results During 18.7 months of follow-up,21 patients were found to be completely seizures-free or with only aura(ClassⅠ),5 patients only had rare seizures(ClassⅡ,less than 3 times a year).And obvious improvement was achieved in 4 patients(ClassⅢ,at least 75% seizures reduction),no significant change was observed in 1 case(ClassⅣ,less than 75% seizures reduction).The satisfactory rate was 83.87%.Conclusion The human umbilical cord mesenchymal stem cells transplantation in the treatment of late traumatic epilepsy can result in a satisfactory clinical effect.