组织工程与重建外科杂志

组织工程与重建外科杂志 >

2009 , Vol. 5 >Issue 2: 86 - 88

DOI: https://doi.org/10.3969/j.issn.1673-0364.2009.04.007

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人工神经移植物丝素蛋白导管的生物相容性的初步研究

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  • 南通大学神经再生重点实验室;

网络出版日期: 2020-07-23

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Preliminary Study on the Biocompatibility of the Silk Fibroin Conduits-Based Nerve Grafts

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  • Jiangsu Key Laboratory of Nerve Regeneration;Nantong University;Nantong 226001;China;

Online published: 2020-07-23

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摘要

目的初步探讨人工神经移植物丝素蛋白导管的生物相容性。方法将丝素蛋白导管植入兔子皮下,术后4周、8周、12周、24周取材,切片,HE染色,观察局部组织反应。结果大体观察和组织切片观察,局部组织反应轻,纤维包裹逐渐变薄,丝素蛋白导管至24周完全降解。结论丝素蛋白导管有良好的生物相容性和可降解性,是理想的人工神经移植物。

关键词： 丝素蛋白; 导管; 生物相容性; 人工神经移植物

本文引用格式

吴坚，严小莉，赵亚红，杨宇民 . 人工神经移植物丝素蛋白导管的生物相容性的初步研究[J]. 组织工程与重建外科杂志, 2009 , 5(2) : 86 -88 . DOI: 10.3969/j.issn.1673-0364.2009.04.007

Abstract

Objective To evaluate the biocompatibility of the silk fibroin-based nerve grafts in vivo.Methods Silk fibroin conduits were subderma implanted,harvested at 4,8,12,and 24 weeks after operation and processed for histologic analysis.Results There was mild inflammatory reaction at the implant sites.Silk fibroin conduits were completely absorbed after 24 weeks.Conclusion Silk fibroin conduit had an excellent compatibility and suitable degradable properties to be used for peripheral nerve regeneration.

Key words： Silk fibroin; Conduit; Biocompatibility; Artificial nerve grafts

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