Objective To explore the clinical application of digital technique in selecting surgical plan of neurofibromatosis. Methods From December 2010 to December 2013, 27 patients with neurofibromatosis were selected. The preoperative CT scans were performed and the three-dimensional images were reconstructed by mimic 16.0 software. Then the three-dimensional models were printed by using rapid prototyping. Based on the three-dimensional models and multidisciplinary analysis, surgical procedures were settled. According to the surgical plan, the operations were completed. Results The computer-assisted technique helped doctors decide the surgical plan in virtual spaces. The good clinical effects were achieved and the average operative time were shortened by 2 hours. Conclusion The digital technique assisting the preoperative design could help understanding the surgical procedures and positioning the extent of the defect. It is worthy of promotion.