Objective To investigate the clinical effect of minimally invasive percutaneous plate internal fixation in tibia fractures of distal 1/3. Methods From April 2011 to April 2013, 29 cases with tibia fractures of distal 1/3 were treated with minimally invasive percutaneous plate internal fixation. The situation of operation, the fracture healing, postoperative Johner-Wruh score, patient satisfaction after operation and the incidence of adverse reactions were evaluated. Results All the patients were followed up for (11.2 ±0.8) months. In the 29 cases, the average operation time was (70.7 ±12.5) min and the average bleeding quantity was (157.3±16.4) ml. The average radiographic healing time was (14.7±2.6) weeks and full weight-bearing time averaged (15.2±3.1) weeks. Johner-Wruh score of patients increased significantly after surgery (P<0.05). The average postoperative satisfaction score was (93.4±2.1). One case of adverse reaction was observed. Conclusion Minimally invasive percutaneous plate osteosynthesis is an effective method for the treatment of tibia fractures of distal 1/3.