Journal of Tissue Engineering and Reconstructive Surgery >

2009 , Vol. 5 >Issue 4: 190 - 194

DOI: https://doi.org/10.3969/j.issn.1673-0364.2009.08.003

Original article

Experimental Study of Immunogenicity of Tissue Engineering Materials by Using Humanized NOD/SCID Mice

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  • 1 Shanghai Jiaotong University School of Medicine;Shanghai Institute of Immunology;Shangh 200025;China. 2 Department of Immunology;Fujian Medical University;Fuzhou 350004;China. 3 Shanghai Tiss Engineering Research and Development Center;Shanghai 200235;China.;

Online published: 2020-07-23

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Abstract

Objective To investigate the immunogenicity of new transplanted materials in vivo by using humanize NOD/SCID mice model. Methods humanized mice model was established by transferred 100×106 human peripheral blo mononuclear cells (PBMC) into NOD/SCID mice. Next day, the mice were received the allotransplantation of pieces of huma skin from plastic surgery patients as positive control group and received tissue engineering materials (silica ge accompanying with human adipose -derived stem cells (ADSCs) as exper...

Key words： NOD/SCID mice; Immunogenicity; Tissue engineering material

Cite this article

ZHANG Qiuyu,SHENG Huiming,CUI Lei,WANG Ying,YING Shuo,LIN Jinbiao,WU Juanjuan,SHEN Baihua WANG Li,LI Ningli . Experimental Study of Immunogenicity of Tissue Engineering Materials by Using Humanized NOD/SCID Mice[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009 , 5(4) : 190 -194 . DOI: 10.3969/j.issn.1673-0364.2009.08.003

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