Original article

Effects of AcSDKP on TGF-β1 Expression in Human Dermal Fibroblasts

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  • Shanghai Sixth People′s Hospital;Shanghai Jiaotong University School of Medicine;Shanghai 200233;China.;

Online published: 2020-07-23

Abstract

Objective To study the effects of N-acetyl-seryl-aspartyl-lysyl-praline (AcSDKP) on TGF-β1 synthesis in human dermal fibroblasts. Methods Human dermal fibroblast after Primary cultures and identification were subjected to AcSDKP (10-7 mol/L, 10-8 mol/L, 10-9 mol/L, 10-10 mol/L, 10-11 mol/L, respectively) treatment. The control group was not seeded AcSDKP. The proliferation of human dermal fibroblasts were detected by WST-8. The expression of TGF-β1 mRNA were analyzed with RT-PCR. TGF-β1 in the supernatant w...

Cite this article

DENG Zhiming,ZHAO Xibin,ZHENGJianghong,DENG Chenliang,DING Zhi,MAO Guangyu,WANG Huidong,YANG Songlin . Effects of AcSDKP on TGF-β1 Expression in Human Dermal Fibroblasts[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009 , 5(4) : 195 -198 . DOI: 10.3969/j.issn.1673-0364.2009.08.004

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