Journal of Tissue Engineering and Reconstructive Surgery >

2020 , Vol. 16 >Issue 3: 204 - 209

DOI: https://doi.org/10.3969/j.issn.1673-0364.2020.03.008

Progress in Targeted Therapy of Low-Flow Vascular Malformation

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  • 1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    2. Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Received date: 2020-04-08

  Revised date: 2020-04-24

  Online published: 2020-06-26

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Abstract

With the introduction of the concept of precision medicine and the breakthrough in the genetics of vascular malformation, developing targeted therapies for low-flow vascular malformation has become a hot spot and urgent task of current research. Low-flow vascular malformation has been confirmed by the presence of somatic activation mutations leading to the continuous activation of the PI3K/AKT/ mTOR pathway, which indicates the possibility of targeted therapies. In this paper, the current researches and applications of targeted drugs in the treatment of low-flow vascular malformation were reviewed.

Key words： Venous malformation; Lymphatic malformation; Targeted therapy; Sirolimus

Cite this article

Hongyuan LIU, Tongxin GE, Xiaoxi LIN . Progress in Targeted Therapy of Low-Flow Vascular Malformation[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020 , 16(3) : 204 -209 . DOI: 10.3969/j.issn.1673-0364.2020.03.008

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