This paper addresses the critical technical requirements in the field of industrial piping stress analysis by conducting a systematic evaluation of the domestically developed intelligent piping stress analysis software Start-Prof， with comparative studies against the international mainstream software CAESARⅡto verify its technical reliability and engineering applicability. Representative piping systems (seawater， crude oil) were selected as case studies， where finite element models under multiple operating conditions were established to investigate stress response characteristics under combined loads including internal pressure， thermal effects， seismic actions， and wind loads. The results demonstrate that Start-Prof maintains consistent trend accuracy with CAESARⅡ，adopts a more conservative approach in secondary stress evaluation， maintains all stress ratios within code limits， and achieves less than 2% deviation in displacement and modal analysis results. These findings provide strong technical support for the subsequent engineering application and promotion of the domestic Start-Prof software.