Laboratories are important bases for scientific research and talent training. With the national standard and requirement for safety management getting higher and higher, how to adapt to the new state security situation and improve the laboratory safety management level is an urgent mission for universities. We conducted a survey of the current situation of laboratory safety management in our school from five aspects: organization and personnel, safety responsibility and system construction, project meetings and safety inspection, safety education, emergency plans and exercises. By analysis of the survey, we put forward a "Five-in-One" safety management system that will provide a reference for how to strengthen the safety management of laboratory.