It has become a social consensus that colleges and universities should change to train applied undergraduates with the popularization of higher education in our country.Experimental teaching plays a vital role in the cultivation of talents in chemistry and related disciplines. Based on the main problems of safety management of the chemistry laboratory, combined with summary and thinking of technology security work in local colleges at the present, the laboratorial safety management and cultural development are preliminarily studied. This paper puts forward to set up the technology security system of laboratory, whose contents contain the laboratory safety management, promoting the quality of teachers, strengthening the safety education for students, establishing the chemicals information management framework and making chemical accident emergency rescue preplan. Creating a laboratory safety culture environment is also necessary, since it has the important sense for providing support for teaching and scientific research work. For chemical laboratories in a university, safety management connotation is very complex; there are a lot of works waiting to be optimized such as hardware resource integration, emergency mechanism and so on.