In order to realize experimental teaching system of “digital logic” course for computer major and resolve the problems with poor cohesion among hardware basic courses and professional courses, and weakness in engineering training, a digital logic simulation experiment platform based on secure encryption algorithm is proposed in this paper. Taking S-DES encryption algorithm secure system as an example, the principle of S-DES is introduced, and a graphical model of encryption algorithm is built by using Quartus II. In addition, the algorithm is programmed by using Visual C++. Simulation results are compared for the two methods. Experiments show that level of experiment course content and students’ consciousness of engineering practice are enhanced by introducing professional knowledge and implementing hardware basic experimental content with project idea.