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产KPC型碳青霉烯酶肺炎克雷伯菌流行现状及分子遗传学研究进展

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  • 同济大学附属第一妇婴保健院检验科,上海 200040

收稿日期: 2017-03-09

  网络出版日期: 2017-10-25

本文引用格式

沈平华, 陈慧芬 . 产KPC型碳青霉烯酶肺炎克雷伯菌流行现状及分子遗传学研究进展[J]. 诊断学理论与实践, 2017 , 16(05) : 544 -548 . DOI: 10.16150/j.1671-2870.2017.05.018

参考文献

[1] Yigit H, Queenan AM, Anderson GJ, et al.Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae[J]. Antimicrob Agents Chemother,2001,45(4):1151-1161.
[2] Kuehn BM."Nightmare" bacteria on the rise in US hospitals, long-term care facilities[J]. JAMA,2013,309(15):1573-1574.
[3] McKenna M. Antibiotic resistance: the last resort[J]. Nature,2013,499(7459):394-396.
[4] Munoz-Price LS, Poirel L, Bonomo RA, et al.Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases[J]. Lancet Infect Dis,2013,13(9):785-796.
[5] Endimiani A, Depasquale JM, Forero S, et al.Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system[J]. J Antimicrob Chemother,2009,64(5):1102-1110.
[6] Naas T, Nordmann P, Vedel G, et al.Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France[J]. Antimicrob Agents Chemother,2005,49(10):4423-4424.
[7] Munoz-Price LS, Poirel L, Bonomo RA, et al.Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases[J]. Lancet Infect Dis,2013,13(9):785-796.
[8] Weterings V, Zhou K, Rossen JW, et al.An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread[J]. Eur J Clin Microbiol Infect Dis,2015,34(8):1647-1655.
[9] Kanerva M, Skogberg K, Ryynänen K, et al. Coincidental detection of the first outbreak of carbapenemase-producing Klebsiella pneumoniae colonisation in a primary care hospital, Finland, 2013[J]. Euro Surveill,2015,20(26)pii:21172.
[10] Wei ZQ, Du XX, Yu YS, et al.Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China[J]. Antimicrob Agents Chemother,2007,51(2):763-765.
[11] Bradford PA, Bratu S, Urban C, et al.Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City[J]. Clin Infect Dis,2004,39(1):55-60.
[12] Hossain A, Ferraro MJ, Pino RM, et al.Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp[J]. Antimicrob Agents Chemother,2004,48(11):4438-4440.
[13] Chiang T, Mariano N, Urban C, et al.Identification of carbapenem-resistant klebsiella pneumoniae harboring KPC enzymes in New Jersey[J]. Microb Drug Resist,2007, 13(4):235-239.
[14] Pope J, Adams J, Doi Y, et al. KPC type beta-lactamase, rural Pennsylvania[J]. Emerg Infect Dis,2006,12(10):1613-1614.
[15] Smith Moland E, Hanson ND, Herrera VL, et al.Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates[J]. J Antimicrob Chemother,2003,51(3):711-714.
[16] Kitchel B, Rasheed JK, Patel JB, et al.Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258[J]. Antimicrob Agents Chemother,2009,53(8):3365-3370.
[17] Tibbetts R, Frye JG, Marschall J, et al.Detection of KPC-2 in a clinical isolate of Proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC beta-lactamase in P. mirabilis[J]. J Clin Microbiol,2008,46(9):3080-3083.
[18] Rasheed JK, Biddle JW, Anderson KF, et al.Detection of the Klebsiella pneumoniae carbapenemase type 2 Carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid[J]. J Clin Microbiol,2008,46(6):2066-2069.
[19] Robledo IE, Aquino EE, Vázquez GJ.Detection of the KPC gene in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii during a PCR-based nosocomial surveillance study in Puerto Rico[J]. Antimicrob Agents Chemother,2011,55(6):2968-2970.
[20] Kaiser RM, Castanheira M, Jones RN, et al.Trends in Klebsiella pneumoniae carbapenemase-positive K. pneumoniae in US hospitals: report from the 2007-2009 SENTRY Antimicrobial Surveillance Program[J]. Diagn Microbiol Infect Dis,2013,76(3):356-360.
[21] Deshpande LM, Rhomberg PR, Sader HS, et al.Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: report from the MYSTIC Program(1999-2005)[J]. Diagn Microbiol Infect Dis,2006,56(4):367-372.
[22] Patel G, Huprikar S, Factor SH, et al.Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies[J]. Infect Control Hosp Epidemiol,2008,29(12):1099-1106.
[23] Qi Y, Wei Z, Ji S, et al.ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China[J]. J Antimicrob Chemother,2011,66(2):307-312.
[24] Li G, Wei Q, Wang Y, et al.Novel genetic environment of the plasmid-mediated KPC-3 gene detected in Escherichia coli and Citrobacter freundii isolates from China[J]. Eur J Clin Microbiol Infect Dis,2011,30(4):575-580.
[25] Zhang X, Lü X, Zong Z.Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage[J]. Diagn Microbiol Infect Dis,2012,73(2):204-206.
[26] Wang D, Hou W, Chen J, et al.Characterization of the blaKPC-2 and blaKPC-3 genes and the novel blaKPC-15 gene in Klebsiella pneumoniae[J]. J Med Microbiol,2014,63(Pt 7):981-987.
[27] Li H, Zhang J, Liu Y, et al. Molecular characteristics of carbapenemase-producing Enterobacteriaceae in China from 2008 to 2011: predominance of KPC-2 enzyme[J]. Diagn Microbiol Infect Dis,2014,78(1):63-65.
[28] Bowers JR, Kitchel B, Driebe EM, et al.Genomic analysis of the emergence and rapid global dissemination of the clonal group 258 Klebsiella pneumoniae Pandemic[J]. PLoS One,2015,10(7):e0133727.
[29] Chiang TT, Yang YS, Yeh KM, et al.Quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing Klebsiella pneumoniae clinical isolates from Taiwan and the United States[J]. J Microbiol Immunol Infect,2016,49(1):83-90.
[30] Yang J, Ye L, Guo L, et al. A nosocomial outbreak of KPC-2-producing Klebsiella pneumoniae in a Chinese hospital: dissemination of ST11 and emergence of ST37, ST392 and ST395[J]. Clin Microbiol Infect,2013 Nov,19(11):E509-E515.
[31] Yu WL, Lee MF, Tang HJ, et al. Emergence of KPC new variants(KPC-16 and KPC-17) andongoing outbreak in southern Taiwan[J]. Clin Microbiol Infect,2015,21(4):347,e5-e8.
[32] Tseng IL, Liu YM, Wang SJ, et al.Emergence of carbapenemase producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013[J]. PLoS One,2015,10(9):e0138471.
[33] Kumar V, Sun P, Vamathevan J, et al.Comparative genomics of Klebsiella pneumoniae strains with different antibiotic resistance profiles[J]. Antimicrob Agents Chemo-ther,2011,55(9):4267-4276.
[34] Liu P, Li P, Jiang X, et al.Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum[J]. J Bacteriol,2012,194(7):1841-1842.
[35] Deleo FR, Chen L, Porcella SF, et al.Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae[J]. Proc Natl Acad Sci U S A,2014,111(13):4988-4993.
[36] Brisse S, Fevre C, Passet V, et al.Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization[J]. PLoS One,2009,4(3):e4982.
[37] Pitout JD, Nordmann P, Poirel L.Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance[J]. Antimicrob Agents Chemother,2015,59(10):5873-5884.
[38] Chen L, Mathema B, Pitout JD, et al.Epidemic Klebsiella pneumoniae ST258 is a hybrid strain[J]. MBio,2014,5(3):e01355-e01314.
[39] Cuzon G, Naas T, Villegas MV, et al.Wide dissemination of Pseudomonas aeruginosa producing beta-lactamase blaKPC-2 gene in Colombia[J]. Antimicrob Agents Chemo-ther,2011,55(11):5350-5353.
[40] Chen L, Mathema B, Chavda KD, et al.Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding[J]. Trends Microbiol,2014,22(12):686-696.
[41] Naas T, Cuzon G, Villegas MV, et al.Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene[J]. Antimicrob Agents Chemother,2008,52(4):1257-1263.
[42] Cuzon G, Naas T, Nordmann P.Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization[J]. Antimicrob Agents Chemo-ther,2011,55(11):5370-5373.
[43] Gootz TD, Lescoe MK, Dib-Hajj F, et al.Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital[J]. Antimicrob Agents Chemother,2009,53(5):1998-2004.
[44] Chen L, Chavda KD, Al Laham N, et al.Complete nucleotide sequence of a blaKPC-harboring IncI2 plasmid and its dissemination in New Jersey and New York hospitals[J]. Antimicrob Agents Chemother,2013,57(10):5019-5025.
[45] Chen L, Chavda KD, Melano RG, et al.Comparative genomic analysis of KPC-encoding pKpQIL-like plasmids and their distribution in New Jersey and New York Hospitals[J]. Antimicrob Agents Chemother,2014,58(5):2871-2877.
[46] Chen YT, Lin JC, Fung CP, et al.KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan[J]. J Antimicrob Chemother,2014,69(3):628-631.
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