目的：分析上海青浦地区呼吸道感染患者9项常见病原体[嗜肺军团菌血清1型(Legionella pneumophila seroygroup 1,Lp1)、肺炎支原体(Mycoplasmal pneumonia,MP)、贝纳柯克斯体（Coxiella burnetii,Cb）、肺炎衣原体(Chlamydia pneumonia,CP)、腺病毒(Adenovirus,ADV)、呼吸道合胞病毒(Respiratory syncytial virus,RSV)、甲型流感病毒(Influenza virus A,INFA)、乙型流感病毒（Iinfluenza virus B, INFB）、副流感病毒(Parainluenza virus,PIV)(1、2和3型)]的检出情况。方法：收集复旦大学附属中山医院青浦分院2015年3月至2016年2月共2 241例呼吸道感染门诊和住院患者的血清标本,采用安图试剂的间接免疫荧光法检测抗体IgM,进行呼吸道9项常见病原体IgM抗体的检测,并从年龄、季节等因素进行分析。结果：2 241例患者中有447例呼吸道病原体阳性,总阳性率为19.95%,其中检出单一病原体者构成比占77.18%(345/447),检出一种病原体以上者占22.82% (102/447)。9项病原体以MP感染的构成比最高,为184例(41.16%);其次是Lp1,为121例（27.07%）。从季节来看,春、夏、秋、冬的以上9种病原体检出率各为16.42%、18.08%、20.72%、23.94%;从年龄来看,<12岁组有166例病原体阳性（21.84%）,12~59岁组有105例病原体阳性（105/646,16.25%）,≥60岁组有176例病原体阳性（176/835,21.08%）。结论：MP是上海青浦各季节呼吸道感染者中检出的主要病原体;<12岁及12~59岁组呼吸道感染的病原体中MP的检出率较高;在夏季检出的病原体中Lp1的检出率较高。

Objective: To analyze the infection rates of 9 commonly seen pathogens [Parainfluenza virus (PIV), Influenza virus A (INFA), Influenza virus B (INFB), Respiratory syncytial virus (RSV), Adenovirus (ADV), Legionella pneumophlia serogroup 1 (Lp1), Mycoplasma pneumoniae (MP), Coxiella burnetii (Cb)], Chlamydophila pneumonia (CP)] among patients with acute respiratory tract infection. Method: A total of 2 241 samples were collected from inpatients at the Qingpu Branch of Zhongshan Hospital, Fudan University during 2015-2016. IgM antibodies of the nine pathogens in inpatients with respiratory infection were detected by indirect immunofluorescence method. The clinical epidemiological characteristics by age group, pathogen type and seasons were analyzed. Results: Of all the 2 241 patients, 447 cases were shown to be positive for the 9 pathogens, with a total positive rate of 19.95%. There were 345 cases (77.18%) with single pathogen infection, and 102 cases (22.82%) with mixed infection. Of the 9 pathogens, constituent ratio of Mp infection was the highest [41.16% (184 cases)], followed by Lp1[121cases (27.07%)]. For seasons by spring, summer, autumn, winter, the positive rates were 16.42%, 18.08%, 20.72%, 23.94%, respectively. In different age groups, the positive rate were 21.84% (<12 years), 16.25% (12-59 years） and 21.08% (≥60 years), respectively. Conclusions: MP is the major pathogen in patients with respiratory tract infection for all 4 seasons. Detection rates of MP in patients with age <12 and 12-59 are the highest,and so is the detection rate of Lp1 during the summer.