原发性干燥综合征患者合并周围神经病变的临床及实验室特点分析
收稿日期: 2018-12-01
网络出版日期: 2019-02-25
基金资助
国家自然科学基金(81273295);国家自然科学基金(81671598);国家自然科学基金(81801601);中华国际医学交流基金会项目(Z-2014-06-2-1620);上海市科委扬帆计划(17YF1417200);中央高校基础研究人才培养计划(22120170163)
Clinical and laboratory analysis of primary Sjögren′s syndrome complicated with neurological lesions
Received date: 2018-12-01
Online published: 2019-02-25
王艳青, 黄琬雪, 梁媛媛, 吴珍珍, 王璇, 汤建平 . 原发性干燥综合征患者合并周围神经病变的临床及实验室特点分析[J]. 诊断学理论与实践, 2019 , 18(1) : 51 -55 . DOI: 10.16150/j.1671-2870.2019.01.010
Objective: To investigate the clinical manifestations, electromyographic abnormalities and laboratory characteristics of primary Sjögren′s syndrome (pSS) complicated with peripheral neuropathy and to analyze the risk factor of pSS complicated with peripheral neuropathy. Methods: A retrospective analysis was performed on 132 pSS patients who met the 2002 American-European Consensus Group criteria for pSS at Tongji Hospital from January 2015 to September 2017. The patients were categorized into group with peripheral neuropathy (pSS-PNS) and group without peripheral neuropathy (pSS-nPNS). The clinical manifestations, corresponding examinations and laboratory characteristics of the two groups were compared. The data were analyzed by t test, χ2 test and logistic regression analysis. Results: A total of 132 patients with pSS were enrolled in this study, including 12 males and 120 females. The ratio of male to female was 1∶10. Among them, 21 patients suffered from peripheral nervous system involvement and the prevalence rate was 15.9%(21/132). There were no significant differences in gender composition, age, onset age and course between the two groups. Compared with the group without peripheral neuropathy, joint swelling and pain (71.4% and 44.1%, P=0.02) were more common in the group with peripheral neuropathy, and CD8 [(21.25±13.11)% and(26.65±9.44)%, P=0.02] decreased significantly, ratio of CD4/CD8(2.80±1.45 vs 1.91±1.12, P=0.04) increased significantly. ESSDAI (European League Against Rheumatism Sjögren′s Syndrome Disease Activity Index) score [(4.71±0.46) and (2.80±0.17) ] was significantly higher in pSS-PNS group. ESSDAI (OR=1.836, 95%CI 1.169-2.883, P=0.008) was an independent risk factor for pSS with peripheral neuropathy. Conclusions: The clinical manifestations of pSS complicated with peripheral neuropathy are diverse, and the disease activity is high. High disease activity is an independent risk factor for Sjögren′s syndrome complicated with peripheral neuropathy.
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