目的 了解原发性干燥综合征（primary Sjögren′s syndrome, pSS）患者合并周围神经（peripheral nervous system）病变的临床特点，探讨pSS合并周围神经病变的危险因素。方法 回顾性分析2015年1月至2017年9月，同济大学附属同济医院风湿免疫科收治且符合2002年美欧协作组提出的干燥综合征分类标准的132例pSS患者。通过临床症状、神经系统查体及肌电图检查明确患者有无神经系统损害，进而将其分为pSS合并周围神经系统病变（primary Sjögren′s syndrome with peripheral nervous system, pSS-PNS）组与未合并周围神经系统病变（primary Sjögren′s syndrome not with peripheral nervous system, pSS-nPNS）组，并比较2组的临床表现、相应检查、实验室特征。结果 132例pSS患者中男性12例，女性120例，男女之比为1∶10，其中21例患者合并有周围神经系统受累(21/132，15.9%)，pSS-PNS与pSS-nPNS组间的性别构成、年龄、起病年龄及病程差异无统计学意义。与pSS-nPNS相比， pSS-PNS组的关节肿痛较为常见（71.4%比44.1%，P=0.02），且CD8水平明显下降[(21.25±13.11) %与（26.65±9.44）%，P=0.02]，CD4/CD8比值明显升高（2.80±1.45比1.91±1.12，P=0.04）。pSS-PNS组的欧洲抗风湿病联盟干燥综合征疾病活动度指数（European League Against Rheumatism Sjögren′s Syndrome Disease Activity Index，ESSDAI）较pSS-nPNS组明显增高[(4.71±0.46)分比（2.80±0.17）分，P<0.001]，且ESSDAI（OR=1.836，95%CI 1.169~2.883，P=0.008）是pSS合并周围神经病变的独立危险因素。结论 pSS-PNS患者的临床表现多样，疾病活动度高，高疾病活动度为pSS-PNS的独立危险因素。

Objective: To investigate the clinical manifestations, electromyographic abnormalities and laboratory characteristics of primary Sjögren′s syndrome (pSS) complicated with peripheral neuropathy and to analyze the risk factor of pSS complicated with peripheral neuropathy. Methods: A retrospective analysis was performed on 132 pSS patients who met the 2002 American-European Consensus Group criteria for pSS at Tongji Hospital from January 2015 to September 2017. The patients were categorized into group with peripheral neuropathy (pSS-PNS) and group without peripheral neuropathy (pSS-nPNS). The clinical manifestations, corresponding examinations and laboratory characteristics of the two groups were compared. The data were analyzed by t test, χ² test and logistic regression analysis. Results: A total of 132 patients with pSS were enrolled in this study, including 12 males and 120 females. The ratio of male to female was 1∶10. Among them, 21 patients suffered from peripheral nervous system involvement and the prevalence rate was 15.9%(21/132). There were no significant differences in gender composition, age, onset age and course between the two groups. Compared with the group without peripheral neuropathy, joint swelling and pain (71.4% and 44.1%, P=0.02) were more common in the group with peripheral neuropathy, and CD8 [(21.25±13.11)% and（26.65±9.44）%, P=0.02] decreased significantly, ratio of CD4/CD8(2.80±1.45 vs 1.91±1.12, P=0.04) increased significantly. ESSDAI (European League Against Rheumatism Sjögren′s Syndrome Disease Activity Index) score [(4.71±0.46) and (2.80±0.17) ] was significantly higher in pSS-PNS group. ESSDAI (OR=1.836, 95%CI 1.169-2.883, P=0.008) was an independent risk factor for pSS with peripheral neuropathy. Conclusions: The clinical manifestations of pSS complicated with peripheral neuropathy are diverse, and the disease activity is high. High disease activity is an independent risk factor for Sjögren′s syndrome complicated with peripheral neuropathy.