目的： 探讨因新型冠状病毒性肺炎疫情封闭管理期间基于正念减压疗法（mindfulness-based stress reduction, MBSR）的心理康复干预,对长期住院轻中度阿尔茨海默病（Alzheimer disease,AD）患者情绪障碍及睡眠状况的影响。目的： 入组2020年1月前收治入院的轻中度AD患者70例,所有入选患者均接受为期8周的基于MBSR心理康复干预,干预时间为2020年2月11日至2020年4月30日。在干预开始前,进行患者一般资料收集,并使用汉密尔顿焦虑量表（Hamilton Anxiety Scale,HAMA）、老年抑郁量表（The 15-item Geriatric Depression Scale,GDS-15）及匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index,PSQI）等评估量表对每位入选患者进行初次评估,为期8周的MBSR干预结束时进行再次评估。在初次评估后,对患者一般资料与初次评估结果进行相关性分析。结果： 根据入组轻中度AD患者的焦虑、抑郁程度、睡眠状况评分与其受教育程度呈负相关（r<-0.4;P≤0.01）;而患者的睡眠状况评分与其焦虑、抑郁程度呈正相关（r>0.4;P≤0.01）。在接受了8周的MBSR干预后,患者的GDS、HAMA、PSQI评分较初次评估时有明显改善（P<0.05）。结论： 在因疫情封闭管理期间,基于MBSR的心理康复干预有助于改善长期住院轻中度AD患者的焦虑、抑郁等情绪障碍和睡眠状况。

Objective: To investigate the effects of MBSR(mindfulness-based stress reduction)-based mental rehabilitation intervention on mood disorders and sleep status of patients with mild to moderate Alzheimer′s disease (AD) in long-term hospital during closed management of COVID-19 pandemic. Methods: A total of 70 patients with mild to moderate AD who were admitted to hospital before January 2020 were enrolled. All patients received an 8-week psychological rehabilitation intervention based on MBSR from February 11, 2020 to April 30, 2020. Prior to the intervention, general patient data were collected, including Hamilton Anxiety Scale(HAMA), The 15-item Geriatric Depression Scale(GDS-15) and Pittsburgh Sleep Quality Index(PSQI) and other assessment scales were used for initial assessment of each enrolled patient, and re-assessment was performed at the end of the 8-week intervention. After the initial assessment, correlation analysis was conducted between general patient data and the results of the initial assessment in patients. Results: It revealed that anxiety, depression, sleep status of patients were negatively correlated with their education level (R<-0.4; P≤0.01); the sleep status score of patients was positively correlated with the degree of anxiety and depression (R>0.4; P≤0.01); GDS, HAMA and PSQI scores of the patients were significantly improved after 8 weeks of intervention compared with the initial evaluation(P<0.05). Conclusions: Mental rehabilitation intervention based on MBSR during closed management due to COVID-19 can improve anxiety, depression and other mood disorders and sleep status of patients with long-term inpatient mild to moderate AD.