目的： 分析非侵入式眼表综合分析仪在干眼诊断中的应用价值。方法： 纳入2017年12月至2018年12月期间我科收治的150例疑似干眼患者,先进行非侵入式检查（采用非侵入式眼表综合分析仪）,再进行传统检查,比较2种方法的泪膜异常检出率。采用Pearson和Spearman分析非侵入式检查结果与干眼相关指标间的关系。结果： 非侵入式检查的泪膜异常检出率明显高于传统检查（90.67%比74.67%,P<0.05）。传统检查测得的泪膜破裂时间（tear break-up time, TBUT）与非侵入式检查测得的非侵入性泪膜破裂时间（noninvasive tear break-up time,NITBUT）呈正相关（r=0.88,P<0.01）;传统检查中的基础泪液分泌试验（Schirmer I test, SIT）结果与NITBUT呈正相关（r=0.54,P<0.01）;非侵入式检查测得的泪河高度（tear meniscus height, TMH）与TBUT、SIT呈正相关（r=0.53,P<0.01;r=0.76,P<0.01）;非侵入式检查中的脂质层分析评分（r=-0.52,P<0.01）、睑板腺缺失评分与TBUT（r=-0.61,P<0.01）呈负相关,但与SIT间无相关性（r=0.25,P=0.15）。结论： 在采用非侵入式眼表综合分析仪检查干眼中,泪膜异常检出率高,并可辅助干眼分型及治疗方案制定。

Objective: To analyze the application value of noninvasive ocular surface analyzer in the diagnosis of dry eye. Methods: A total of 150 patients suspected of dry eye from December 2017 to December 2018 were enrolled. All the patients were examined with noninvasive ocular surface analyzer(non-invasive method), and traditional invasive examination was then performed. The detection rate of tear film abnormality was compared between the two methods. Pearson and Spearman analysis was used to analyze the relationship between results of noninvasive method and indice of dry eye. Results: The detection rate of tear film abnormality by non-invasive method (90.67%) was significantly higher than that by traditional invasive examination(74.67%)(P<0.05). Tear break-up time (TBUT) by traditional invasive examination was positively correlated with the noninvasive tear break-up time (NITBUT) (r=0.88, P<0.01）. Schirmer I test (SIT ) by traditional invasive examination was positively correlated with NITBUT（r=0.54, P<0.01）. Tear meniscus height (TMH) by non-invasivemethod was positively correlated with TBUT and SIT（r=0.53, P<0.01; r=0.76, P<0.01）. Scores of lipid layer ana-lysis and meibomian gland loss were negatively correlated with TBUT（r=-0.61, P<0.01）, but had no relationship with SIT（r=0.25, P=0.15）. Conclusions: Detection rate of tear film abnormality by non-invasive ocular surface analyzer is higher than that by traditional invasive examination, and can assist the classification and formulating of treatment of dry eye.