目的： 研究3q26 rs12696304基因多态性与急性心力衰竭（急性心衰）患者1年预后间的关系。方法： 2012年3月至2016年4月间,收集南京医科大学第一附属医院收治的336例急性心衰患者（≥60岁）。采用TaqMan荧光探针实时定量聚合酶链式反应（polymerase chain reaction,PCR）技术法检测患者外周血DNA中的3q26 rs12696304基因多态性, 采用Kaplan-Meier法和log-rank检验,分析不同遗传模型下各基因型急性心衰患者1年的生存率;采用多因素Cox回归分析探讨3q26 rs12696304基因多态性与急性心衰患者1年预后间的相关性。结果： 在共显性遗传模型中,携带杂合子CG基因型的急性心衰患者其1年生存率（74.8%）比携带纯合子GG基因型患者（85.4%）低（CG比GG,P=0.027）;在显性遗传模型中,携带CG+CC基因型急性心衰患者其生存率（74.9%）较纯合子GG基因型患者生存率（85.4%） 明显下降（P=0.023）,CC+CG基因型急性心衰患者发生死亡的风险系数是GG基因型患者的2.45倍[风险比（hazard ratio,HR）=2.45,95%CI为1.24~4.84,P=0.010]。结论： 检测3q26 rs12696304基因多态性可能有助于评估中国南方汉族老年人群中急性心衰患者1年的预后情况。

Objective: To investigate the correlation between the gene polymorphism of rs12696304 in chromosome 3q26 and 1-year survival rate in the patients with acute heart failure (AHF). Methods: A total of 336 elderly patients of Han population in South China (aged≥60 years) with AHF were enrolled during March 2012 and April 2016. DNA of each patient was extracted from peripheral blood, and the gene polymorphism of rs12696304 was analyzed by real-time fluorescence quantitative PCR with TaqMan probe. One-year survival rate was compared between the patients with diffe-rent gene typing in multiple genetic models using Kaplan-Meier and log-rank test. The Cox regression analysis was used to assess relation between the gene polymorphism of rs12696304 and 1-year survival rate in the patients with AHF. Results: In the co-dominant genetic model, the 1-year survival rate of the AHF patients carrying heterozygous CG genotypes was lower than that of patients carrying wild homozygous GG genotypes (74.8% vs 85.4%, P=0.027). In the dominant genetic model, 1-year survival rate of the AHF patients carrying CG+CC genotype was significantly lower than that of patients carrying the wild homozygous GG genotype (74.9% vs 85.4%, P=0.023). Further Cox regression analysis showed that the risk of 1-year death in the AHF patients carrying CG+CC genotype was 2.45 times of that in the patients with GG genotype (HR=2.45, 95%CI: 1.22-4.95, P=0.012) after adjustment with the relevant variables in codominant model, and in the dominant model, the risk of 1-year death was also 2.45 times of that in patients with GG genotype (HR=2.45, 95%CI: 1.24-4.84, P=0.010). Conclusions: The gene polymorphisms of rs12696304 located in chromosome 3q26 region may be associated with the 1-year prognosis in the patients with AHF.