论著

眼部蠕形螨感染与继发性免疫缺陷病相关性的研究

展开
  • 1.复旦大学附属中山医院厦门医院眼科,福建 厦门 361000
    2.复旦大学附属中山医院眼科,上海 200032

收稿日期: 2020-05-20

  网络出版日期: 2022-07-15

The correlation of ocular Demodex folliculorum infection with secondary immunodeficiency diseases

Expand
  • 1. Department of Ophthalmology, Xiamen Branch, Zhongshan Hospital, Fudan University, Fujian Xiamen 361000, China
    2. Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Received date: 2020-05-20

  Online published: 2022-07-15

摘要

目的: 观察继发性免疫缺陷疾病患者眼部蠕形螨的感染情况,分析眼部蠕形螨感染与继发性免疫缺陷病间的相关性。方法: 选择2019年11月至2020年1月间复旦大学附属中山医院厦门医院内外科诊治的存在继发性免疫缺陷的患者192例作为研究对象,其中包括恶性肿瘤、慢性肾病、糖尿病、自身免疫病患者;另从来我院就诊的无全身性基础疾病的人群中随机选取246例作为对照者。本研究采用拔取眼部睫毛,在光学显微镜下检查蠕形螨及虫卵,确定眼部蠕形螨感染情况。结果: 192例继发性免疫缺陷患者中有眼部蠕形螨感染者为162例,阳性率为84.4%;246例对照者中有眼部蠕形螨感染者为150例,阳性率为61.0%,2组间差异有统计学意义(P<0.05)。眼部蠕形螨感染与继发性免疫缺陷疾病呈正相关(r=0.256,P<0.001)。其中,糖尿病患者的眼部蠕形螨感染率最高,为89.7%。变量相关性分析提示,眼部蠕形螨感染与继发性免疫缺陷疾病呈正相关(r=0.256,P<0.001);多因素Logistic回归分析提示,患有继发性免疫缺陷疾病患者感染眼部蠕形螨的风险是未患继发性免疫缺陷疾病的2.09倍(OR=2.09,95%CI为1.25~3.47,P=0.005)。结论: 继发性免疫缺陷病可能是眼部蠕形螨感染的高危因素,糖尿病患者需注意眼部蠕形螨的检查。

本文引用格式

洪玉芳, 吴漾, 许雍棠, 姚鹏翔, 陈振宗, 马晓萍 . 眼部蠕形螨感染与继发性免疫缺陷病相关性的研究[J]. 诊断学理论与实践, 2020 , 19(04) : 430 -433 . DOI: 10.16150/j.1671-2870.2020.04.020

Abstract

Objective: To investigate the correlation between ocular Demodex folliculorum infection and secondary immunodeficiency diseases. Methods: A total of 192 patients with secondary immunodeficiency diseases from Xiamen Branch, Zhongshan Hospital, Fudan University during November 2019 to January 2020 were enrolled, including patients with malignant tumors, chronic kidney disease, diabetes, and autoimmune diseases. Two hundred and forty-six visited patients without secondary immunodeficiency diseases were served as controls. The eye lashes were taken and examined under optical microscope to observe the status of Demodex folliculorum infection. Results: Demodex folliculorum was found in 162 of 192 patients (84.4%) with secondary immunodeficiency diseases and 150 of 246 controls(61.0%)(P<0.05). Among these subjects, patients with diabetes had the highest infection rate (89.7%). The variable correlation analysis revealed that immunodeficiency diseases was positively correlated with Demodex folliculorum infection(r=0.256, P<0.001). Multivariate Logistic regression analysis showed that the secondary immunodeficiency diseases doubled the risk of ocular Demodex folliculorum infection (OR=2.09, 95%CI 1.25-3.47, P=0.005). Conclusions: Secondary immunodeficiency may be a high-risk factor for the ocular infection with Demodex folliculorum, and attention should be given to Demodex folliculorum examination in diabetes patients.

参考文献

[1] 沈满意, 马晓萍. 眼部蠕形螨的研究进展[J]. 复旦学报(医学版), 2018, 45(4):585-589.
[2] 亚洲干眼协会中国分会, 海峡两岸医药交流协会眼科专业委员会眼表与泪液病学组. 我国蠕形螨睑缘炎诊断和治疗专家共识(2018年)[J]. 中华眼科杂志, 2018, 54(7):491-495.
[3] Czepita D, Kuźna-Grygiel W, Czepita M, et al. Demodex folliculorum and Demodex brevis as a cause of chronic marginal blepharitis[J]. Ann Acad Med Stetin, 2007, 53(1):63-67.
[4] 高莹莹, 许锻炼, 黄丽娟, 等. 睑缘鳞屑与眼睑蠕形螨寄居关系的临床分析[J]. 中华眼科杂志, 2009, 45(9):834-835.
[5] Peacock ME, Arce RM, Cutler CW. Periodontal and other oral manifestations of immunodeficiency diseases[J]. Oral Dis, 2017, 23(7):866-888.
[6] Sönmez ÖU, Yalçın ZG, Karakeçe E, et al. Associations between Demodex species infestation and various types of cancer[J]. Acta Parasitol, 2013, 58(4):551-555.
[7] 邢杰, 闫玉文. 寄生虫感染与免疫缺陷病研究进展[J]. 医学综述, 2001, 7(1):24-25.
[8] 王惠秋, 李春华, 吕圣秀. 艾滋病相关卡氏肺孢子菌肺炎的诊断进展[J]. 检验医学与临床, 2018, 15(19):2977-2979.
[9] 田庚善. 免疫缺陷性感染的诊断及治疗[M]//斯崇文、田庚善主编. 现代传染病治疗学. 合肥: 安徽科学技术出版社, 1998,137-147.
[10] Kaya S, Selimoglu MA, Kaya OA, et al. Prevalence of Demodex folliculorum and Demodex brevis in childhood malnutrition and malignancy[J]. Pediatr Int, 2013, 55(1):85-89.
[11] Erbagci Z, Erbagci I, Erkiliç S. High incidence of demodicidosis in eyelid basal cell carcinomas[J]. Int J Dermatol, 2003, 42(7):567-571.
[12] Clifford CW, Fulk GW. Association of diabetes, lash loss, and Staphylococcus aureus with infestation of eyelids by Demodex folliculorum (Acari: Demodicidae)[J]. J Med Entomol, 1990, 27(4):467-470.
[13] 姚梦, 刘鹏, 蒲凤, 等. T淋巴细胞亚群分析在免疫缺陷病患者中的应用及临床意义[J]. 卫生职业教育, 2020, 38(1):155-157.
[14] Yagdiran Düzgün O, Aytekin S. Comparison of Demodex folliculorum density in haemodialysis patients with a control group[J]. J Eur Acad Dermatol Venereol, 2007, 21(4):480-483.
文章导航

/