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染色体9p21多态性与急性非心源性脑梗死患者颈动脉斑块的易感性分析

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  • 1.新疆喀什地区第二人民医院神经内科,新疆 喀什地区 844000;
    2.复旦大学附属华山医院 神经内科,上海 200040;
    3.上海交通大学医学院附属瑞金医院神经内科,上海 200025
*: 并列第一作者

收稿日期: 2016-08-31

  网络出版日期: 2022-07-27

基金资助

新疆维吾尔族自治区自然科学基金(2015211C223)

Analysis on relationship between polymorphism of chromosome region 9p21 and susceptibility of carotid plaque in acute non-cardioembolic cerebral infarction patients

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  • 1. Department of Neurology, the Second People's Hospital of Kashgar, Xinjiang Kashgar 844000, China;
    2. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China;
    3. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2016-08-31

  Online published: 2022-07-27

摘要

目的: 探讨急性非心源性脑梗死患者染色体9p21区域rs10757274、rs7044859、rs4977574和rs496892基因多态性与颈动脉斑块的相关性。方法: 应用聚合酶链反应-连接酶检测反应(polymerase chain reaction-ligase detection reaction, PCR-LDR)对新疆和上海地区共411例急性非心源性脑梗死患者(无颈动脉斑块组181例,伴有颈动脉斑块组230例)的染色体9p21区域rs10757274、rs7044859、rs4977574和rs496892这4个位点进行基因多态性分析。结果: 在新疆和上海地区的中老年脑梗死患者中,颈动脉斑块组的携带rs4977574的G等位基因百分比明显多于无颈动脉斑块组,分别是52.6% 比41.7%(校正后P=0.006);颈动脉斑块组患者rs4977574的GG基因型携带百分比高于无颈动脉斑块组,分别是26.5%比 20.4%(P=0.002)。位点rs10757274与rs4977574之间、位点rs7044859与 rs496892之间存在强的连锁不平衡关系。结论: 在新疆和上海地区的中老年脑梗死患者中,染色体9p21区带中rs4977574的基因多态性与颈动脉斑块的发生可能有一定关联。

本文引用格式

买买提依明, 热西旦, 陈波, 张祥, 马卫英, 杨康, 傅毅 . 染色体9p21多态性与急性非心源性脑梗死患者颈动脉斑块的易感性分析[J]. 诊断学理论与实践, 2016 , 15(05) : 498 -502 . DOI: 10.16150/j.1671-2870.2016.05.013

Abstract

Objective: To analyze the relationship between gene polymorphism of chromosome region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque in acute non-cardioembolic cerebral infarction patients. Methods: The gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed with polymerase chain reaction-ligase detection reaction (PCR-LDR) in 411 acute non-cardioembolic cerebral infarction patients (230 with carotid plaque while 181 without). Results: Compared with those without carotid plaque, an increased frequency in the G allele of rs4977574 was seen in patients with carotid plague group(52.6% vs 41.7%) (adjusted P=0.006), as well as the frequency in GG allele of rs4977574 genotype (26.5% vs 20.4%) (P=0.002). Strong linkage disequilibrium existed not only between rs10757274 and rs4977574, but also between rs7044859 and rs496892. Conclusions: Genetic polymorphism of rs4977574 on 9p21 is potentially associated with carotid plaque in patients with non-cardioembolic cerebral infarction in Xinjiang and Shanghai.

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