病例报告

阴道壁胃肠道外间质瘤一例报道并文献复习

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  • 1.山东第一医科大学附属东阿医院(东阿县人民医院)病理科,山东 252201
    2.山东省第二人民医院病理科,山东 250022

收稿日期: 2021-09-15

  网络出版日期: 2022-08-17

The extra-gastrointestinal stromal tumors located in vagina: A case report and literature review

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  • 1. Department of Pathology, Dong′e County People′s Hospital, Shandong First Medical University, Shandong 252201, China
    2. Department of Pathology, The Second People′s Hospital of Shandong Province, Shandong 250022, China

Received date: 2021-09-15

  Online published: 2022-08-17

摘要

胃肠道外间质瘤(extra-gastrointestinal stromal tumor,EGIST)是发生于胃肠道外较少见的间叶组织肿瘤,其与胃肠道间质瘤的免疫表型、组织学形态、基因突变位点及突变频率相似。EGIST患者缺乏典型的临床特征,不易明确诊断,并且由于报道病例较少,尚未有统一的危险度评估标准。本文报道1例原发于阴道壁的EGIST,结合患者的临床资料,采用免疫组化标志物检测得以确诊。复习相关文献后进行综合分析,提示EGIST具有低的发病率,预后较胃肠间质瘤差。

本文引用格式

郭业兵, 郑金峰 . 阴道壁胃肠道外间质瘤一例报道并文献复习[J]. 诊断学理论与实践, 2022 , 21(03) : 405 -407 . DOI: 10.16150/j.1671-2870.2022.03.020

Abstract

Extra-gastrointestinal stromal tumor(EGIST) is a relatively rare mesenchymal tumor occurring outside the gastrointestinal tract. The immunophenotype, histological morphology, gene mutation sites and mutation frequency of EGIST are similar to GIST. EGIST lacks typical clinical features and is not easily diagnosed. Due to the small number of reported cases, there is no unified risk assessment standard. A case of EGIST originating in vaginal wall is reported in this paper, which diagnosis depended on clinical data and immunohistochemical markers. Literature reviewing suggestes that the incidence of EGIST is low and patients with EGIST have worse prognosis.

参考文献

[1] Monabati A, Safavi M, Solhjoo F. Extragastrointestinal stromal tumor presenting as omental cyst[J]. J Gastrointest Surg, 2016, 20(6):1275-1277.
[2] Miettinen M, Monihan JM, Sarlomo-Rikala M, et al. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases[J]. Am J Surg Pathol, 1999, 23(9):1109-1118.
[3] 师英强, 梁小波. 胃肠道间质瘤[M]. 人民卫生出版社, 2011:62-67.
[3] Shi Y Q, Liang XB. Gastrointestinal stromal tumor[M]. People′s Medical Publishing House, 2011:62-67.
[4] Sakurai S, Hishima T, Takazawa Y, et al. Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum[J]. Pathol Int, 2001, 51(7):524-531.
[5] Goh BK, Chow PK, Kesavan SM, et al. A single-institution experience with eight CD117-positive primary extragastrointestinal stromal tumors: critical appraisal and a comparison with their gastrointestinal counterparts[J]. J Gastrointest Surg, 2009, 13(6):1094-1098.
[6] Shi J, Fu R, Hec W, et al. Recurrent extra-gastrointestinal stromal tumor of the vagina: a case report and review of the literature[J]. Niger J Clin Pract, 2020, 23(12):1776-1779.
[7] 郭艳敏, 周梅香, 石瑞芳. 原发性胃肠外间质瘤5例临床病理分析[J]. 临床与病理杂志, 2020, 40(7):1912-1916.
[7] Guo YM, Zhou MX, Shi RF. Clinicopathological analysis of primary extragastrointestinal stromal tumor: 5 case reports[J]. J Clin Pathol Res, 2020, 20(7):1912-1916.
[8] 何纯刚, 陈利生, 李君, 等. 胃肠道外间质瘤的临床特征、治疗与预后[J]. 中华普通外科杂志, 2007, 22(8):579-581.
[8] He CG, Chen LS, Li J, et al. The clinical characteristics treatment and prognosis of extra-gastrointestinal stromal tumors[J]. Chin J Gen Surg, 2007, 22(8):579-581.
[9] 刘立成, 刘雅刚, 徐文通. 胃肠道外间质瘤临床病理特征、治疗方法对预后的影响[J]. 现代肿瘤医学, 2021, 29(6):1556-1559.
[9] Liu LC, Liu YG, Xu WH. Effect of clinicopathological features and therapeutic methods on prognosis in extra-gastrointestinal stromal tumor[J]. J Mod Oncol, 2021, 29(6):1566-1559.
[10] Tsuda H, Kawabata M, Yamamoto K, et al. Prospective study to compare endometrial cytology and transvaginal ultrasonography for identification of endometrial malignancies[J]. Gynecol Oncol, 1997, 65(3):383-386.
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