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1990年至2020年间全球及我国肺癌的发病流行趋势及防控措施

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  • 复旦大学附属肿瘤医院肿瘤预防部 复旦大学上海医学院肿瘤学系上海市级医院肿瘤专科联盟,上海肿瘤疾病人工智能工程技术研究中心,上海 200032

收稿日期: 2022-12-30

  网络出版日期: 2023-07-06

基金资助

上海市老龄化和妇儿健康研究专项(2020YJZX0206);中国癌症基金会科研项目(NH2018001)

Lung cancer worldwide and in China from 1990 to 2020: prevalence and prevention measures

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  • Department of Cancer Prevention, Department of Oncology, Shanghai Municipal Hospital, Oncological Specialist Alliance, Fudan University Shanghai Cancer Center, Shanghai Engineering Research Center of Artificial Intelligence Technology for Tumor Diseases, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received date: 2022-12-30

  Online published: 2023-07-06

摘要

1990年至2020年间,全球肺癌新发病例数不断增长,其间发病率保持稳定,但全球肺癌发病呈现性别、地区、年龄、组织学类型分布变化趋势。男、女发病率数据差异不断缩小,男性世界人口年龄标化发病率(世标发病率)下降12.5%,女性世标发病率上升22.3%。1998年至2012年,肺癌的发病具有明显的地区差异,欧洲、亚洲和北美洲的男性肺癌世标发病率均有下降趋势,平均年度变化百分比分别为-1.6%、-0.6%和-2.5%;而女性肺癌发病率,除了北美洲表现出下降趋势,其他地区则呈现出上升趋势。1998年至2012年,全球各地区的肺癌平均发病年龄均呈现逐年递增的趋势,亚洲男性的肺癌平均发病年龄增幅最大,从1998年的67.21岁增加到2012年的69.14岁。20世纪80年代初期开始,鳞状细胞癌占肺癌的构成比就呈现下降趋势,2004年起,腺癌已成为世界上最常见的肺癌组织学类型。2020年,我国是全球每年新发肺癌病例数最多的国家,达539 181例。1989年至2008年,我国城乡肺癌发病率比由2.07降至1.14,城乡间的肺癌发病水平差异已明显缩小;我国经济欠发达地区,肺癌的发病率在上升,而一些肺癌高发地区则得到了控制。我国作为全球最大的烟草生产国和消费国,烟草的控制形势严峻,控制职业暴露也是我国预防肺癌发生的关键,环境污染造成肺癌的风险逐步走低,建立肺癌危险因素的监测网络是未来发展的方向。

本文引用格式

王泽洲, 郑莹 . 1990年至2020年间全球及我国肺癌的发病流行趋势及防控措施[J]. 诊断学理论与实践, 2023 , 22(01) : 1 -7 . DOI: 10.16150/j.1671-2870.2023.01.001

Abstract

From 1990 to 2020, the number of newly diagnosed cases of lung cancer in the world continued to grow, but the prevalence remained stable. As time went, the incidence (world standard incidence, adjusted with age structure of world population) of lung cancer changed in gender, region, age, and histological type. The difference between male and female in incidence continued to narrow, with male incidence declining by 12.5% and female incidence rising by 22.3%. There were obvious regional differences in the incidence of lung cancer. From 1998 to 2012, the incidence of male lung cancer in Europe, Asia and North America showed a downward trend (the average annual change percentages were -1.6%, -0.6% and -2.5%, respectively), while the incidence of female lung cancer showed a upward trend except North America. From 1998 to 2012, the average age of lung cancer patients in all regions of the world showed a trend of increasing year by year. The average age at diagnosis of lung cancer in Asian men increased from 67.21 years in 1998 to 69.14 years in 2012. Patterns of histological types of lung cancer have also changed. Since the early 1980s, the proportion of squamous cell lung cancer has declined. Since 2004, adenocarcinoma has become the most common histological type of lung cancer in the world. In 2020, China had the largest cases of newly diagnosed lung cancer in the world. From 1989 to 2008, urban-rural ratio of lung cancer incidence dropped from 2.07 to 1.14. In economically underdeveloped areas, the incidence of lung cancer was also rising, and the situation in some areas with high incidence of lung cancer had been controlled. China, as the largest tobacco producer and consumer country, has to be serious with the control of tobacco. Risk of lung cancer caused by environmental pollution is gradually lower. Controlling occupational exposure is also the key to preventing lung cancer in China, and establishing a mornitoring network for risk factors is the direction in future.

参考文献

[1] SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71(3):209-249.
[2] GBD 2019 Respiratory Tract Cancers Collaborators. Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet Respir Med, 2021, 9(9):1030-1049.
[3] THUN M J, HANNAN L M, ADAMS-CAMPBELL L L, et al. Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies[J]. PLoS Med, 2008, 5(9):e185.
[4] SRIPLUNG H, SONTIPONG S, MARTIN N, et al. Cancer incidence in Thailand, 1995-1997[J]. Asian Pac J Cancer Prev, 2005, 6(3):276-281.
[5] 梁锌, 刘梦雯, 张丽, 等. 全球部分地区肺癌发病趋势及年龄变化情况分析[J]. 中国肿瘤, 2022, 31(9):683-692.
[5] LIANG X, LIU M W, ZHANG L, et al. Global trends of incidence of lung cancer[J]. China Cancer, 2022, 31(9):683-692.
[6] JEMAL A, MILLER K D, MA J, et al. Higher lung cancer incidence in young women than young men in the United States[J]. N Engl J Med, 2018, 378(21):1999-2009.
[7] FIDLER-BENAOUDIA M M, TORRE L A, BRAY F, et al. Lung cancer incidence in young women vs. young men: A systematic analysis in 40 countries[J]. Int J Cancer, 2020, 147(3):811-819.
[8] KREYBERG L. Histological lung cancer types. A morphological and biological correlation[J]. Acta Pathol Microbiol Scand Suppl, 1962, Suppl 157:1-92.
[9] LORTET-TIEULENT J, SOERJOMATARAM I, FERLAY J, et al. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women[J]. Lung Cancer, 2014, 84(1):13-22.
[10] ZHENG R, ZHANG S, ZENG H, et al. Cancer incidence and mortality in China, 2016[J]. JNCC, 2022, 2(1):1-9.
[11] 李翔, 高申. 1990-2019年中国居民肺癌发病、患病和死亡趋势分析[J]. 中国慢性病预防与控制, 2021, 29(11):821-826.
[11] LI X, GAO S. Trend analysis of the incidence,morbidity and mortality of lung cancer in China from 1990 to 2019[J]. Chin J Prev Control Chronic Dis, 2021, 29(11):821-826.
[12] 韩仁强, 郑荣寿, 张思维, 等. 1989年-2008年中国肺癌发病性别、城乡差异及平均年龄趋势分析[J]. 中国肺癌杂志, 2013, 16(09):445-451.
[12] HAN R Q, ZHEN R S, ZHANG S W, et al. Trend analyses on the differences of lung cancer incidence between gender, area and average age in China during 1989-2008[J]. Chin J Lung Cancer, 2013, 16(09):445-451.
[13] 袁延楠, 杨雷, 刘硕, 等. 2000-2012年北京市居民肺癌发病特征及变化趋势[J]. 中华预防医学杂志, 2018, 52(7):691-696.
[13] YUAN Y N, YANG L, LIU S, et al. Analyses on the diffe-rence and trend of lung cancer incidence in Beijing, 2000-2012[J]. Chin J Prev Med, 2018, 52(7):691-696.
[14] 廖美琳, 陈智伟, 郑莹, 等. 中国上海人群肺癌发病的时间趋势及预后因素[J]. 中华医学杂志, 2007, 87(27):1876-1880.
[14] LIAO M L, CHEN Z W, ZHENG Y, et al. Incidence, time trend, survival, and predictive factors of lung cancer in Shanghai populations[J]. Natl Med J China, 2007, 87(27):1876-1880.
[15] 许欢, 林国桢, 李科, 等. 广州市2005-2013年肺癌发病趋势分析[J]. 肿瘤预防与治疗, 2017, 30(2):112-115,126.
[15] XU H, LIN G Z, LI K, et al. An analysis of the incidence trend of lung cancer in Guangzhou,2005-2013[J]. J Cancer Control Treat, 2017, 30(2):112-115,126.
[16] 张思维, 郑荣寿, 杨之洵, 等. 2000—2014年中国肿瘤登记地区肺癌发病年龄变化趋势分析[J]. 中华预防医学杂志, 2018, 52(6):579-585.
[16] ZHANG S W, ZHENG R S, YANG Z X, et al. Trend analysis on incidence and age at diagnosis for lung cancer in cancer registration areas of China, 2000-2014[J]. Chin J Prev Med, 2018, 52(6):579-585.
[17] 孔祥应, 周棉勇, 黄军, 等. 1999-2018年黔南州居民肺癌发病趋势分析[J]. 现代预防医学, 2020, 47(8):1364-1367,1375.
[17] KONG X Y, ZHOU M Y, HUANG J, et al. Trend in lung cancer incidence among residents in Qiannan areas of Guizhou between 1999 and 2018[J]. Mod Prev Med, 2020, 47(8):1364-1367,1375.
[18] SIEGEL R L, MILLER K D, FUCHS H E, et al. Cancer statistics, 2022[J]. CA Cancer J Clin, 2022, 72(1):7-33.
[19] Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021[R/OL]. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatistics.
[20] HORINOUCHI H, KUSUMOTO M, YATABE Y, et al. Lung Cancer in Japan[J]. J Thorac Oncol, 2022, 17(3):353-361.
[21] JEMAL A, THUN M J, RIES L A, et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control[J]. J Natl Cancer Inst, 2008, 100(23):1672-1694.
[22] PATHANIA V S. Women and the smoking epidemic: turning the tide[J]. Bull World Health Organ, 2011, 89(3):162.
[23] GAO S, LI N, WANG S, et al. Lung cancer in People's Republic of China[J]. J Thorac Oncol, 2020, 15(10):1567-1576.
[24] WANG M, LUO X, XU S, et al. Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013[J]. Lancet Respir Med, 2019, 7(1):35-45.
[25] ISEN A, ROSSIN-SLATER M, WALKER W R. Every breath you take every dollar you’ll make: The long-term consequences of the clean air act of 1970[J]. J Pol Economy, 2017, 125(3):848-902.
[26] ZHANG Y, LI J, LI Z K, et al. Impact of coronavirus disease 2019 on clinical characteristics in patients with lung cancer: a large single-centre retrospective study[J]. Front Oncol, 2021, 11:693002.
[27] WEI W, ZENG H, ZHENG R, et al. Cancer registration in China and its role in cancer prevention and control[J]. Lancet Oncol, 2020, 21(7):e342-e349.
[28] Surveillance, Epidemiology, and End Results Program. Surveillance research program, National Cancer Institute[EB/OL]. [2022-12-28]. DCCPS, Surveillance Research Program. https://seer.cancer.gov/explorer/.
[29] Centers for Disease Control and Prevention. 2021 BRFSS Survey Data and Documentation[EB/OL]. [2022-12-28]. https://www.cdc.gov/brfss/annual_data/annual_2021.html.
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