论著

十二指肠型滤泡性淋巴瘤17例临床病理特征及预后分析

展开
  • 上海交通大学医学院附属瑞金医院病理科,上海 200025

收稿日期: 2022-05-11

  网络出版日期: 2023-12-18

基金资助

上海市科技计划项目(21ZR1440100)

Clinicopathological features and prognosis of 17 cases of duodenal-type follicular lymphoma

Expand
  • Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2022-05-11

  Online published: 2023-12-18

摘要

目的: 探讨十二指肠型滤泡性淋巴瘤(duodenal-type follicular lymphoma, DFL)的临床病理学特征及预后。方法: 回顾性分析17例DFL患者的临床特点、内镜表现、病理学特征及治疗方案,并进行随访。结果: 17例DFL患者中,男性8例,女性9例,男女比为1∶1.125,中位年龄为58岁(33~67岁),其中13例DFL患者是在常规体检中发现,内镜下多表现为颗粒状增生。DFL发生在十二指肠者有15例(88.2%),且全部位于十二指肠降段;单发病灶15例,多发病灶2例。内镜下,见病变位于黏膜层或黏膜下层,呈清楚或隐约的“膨胀性”生长,可见滤泡样结节,结节内由中心细胞样细胞和散在中心母细胞样细胞组成,相当于经典型滤泡性淋巴瘤的1级或2级。肿瘤细胞表达CD20、CD79a、CD10、BCL6及BCL2,9例患者的CD21染色显示滤泡树突网在肿瘤性滤泡周边密集、浓染,而在中央淡染、稀疏,Ki-67低表达。4例患者行第二代基因测序检测,其中3例共同检测到CREBBP基因变异。14例患者未经任何治疗,疾病无进展;1例行局部肠段切除,术后未行化疗和放疗,未复发;1例接受化疗加利妥昔单抗治疗,病变完全消退。结论: DFL多为单发病灶,镜下表现类似经典型滤泡性淋巴瘤1级或2级,较特殊的免疫表型是CD21常在肿瘤性滤泡周边更密集、深染,具有惰性生物学行为。

本文引用格式

刘英婷, 易红梅, 王雪, 杨春雪, 欧阳斌燊, 许海敏, 王朝夫 . 十二指肠型滤泡性淋巴瘤17例临床病理特征及预后分析[J]. 诊断学理论与实践, 2023 , 22(04) : 362 -368 . DOI: 10.16150/j.1671-2870.2023.04.005

Abstract

Objective: To investigate the clinicopathological features and prognosis of duodenal-type follicular lymphoma (DFL). Methods: The clinical features, endoscopic appearances, pathological features, and treatments of 17 patients with DFL were retrospectively analyzed and followed up. Results: Among the 17 cases of DFL, there were 8 males and 9 females, with a male-to-female ratio of 1∶1.125. The median age was 58 years (33-67 years). Among them, 13 patients with DFL were found in routine physical examination, and most of them showed granular hyperplasia under endoscopy. Among the cases, 15 (88.2%) occurred in the duodenum, and all were located in the descending part of the duodenum. There were 15 cases of single lesions and 2 cases of multiple lesions. Under the microscope, the lesions were located in the mucosal layer or submucosal layer, with a clear or vague “expansive” growth pattern and visible follicular nodules. The nodules were composed of centrocyte-like cells and scattered centroblast-like cells, equivalent to grade 1 or 2 of classical follicular lymphoma. The tumor cells expressed CD20, CD79a, CD10, BCL6, and BCL2. CD21 staining of 9 cases showed that the follicular dendrite network was densely stained around the neoplastic follicles, but lightly stained and sparse in the center. Ki-67 expression was low. Four cases underwent second-generation gene sequencing, among which three cases had detected CREBBP gene mutations. Fourteen cases did not receive any treatment, and disease did not progress. One case underwent local intestinal segment resection without postoperative chemotherapy or radiotherapy and did not relapse. One case received chemotherapy and rituximab treatment, and the lesion completely disappeared. Conclusions: Most of DFL lesions are single lesions with microscopic manifestations similar to those of typical follicular lymphoma grade 1 or grade 2. The special immunophenotype is CD21, which is often more dense and deeply stained around the neoplastic follicles, and has inert biological behavior.

参考文献

[1] SWERDLOW S H, World Health Organization, International Agency for Research on Cancer. WHO classification of tumours of haematopoietic and lymphoid tissues[M]. 4th. Lyon: International Agency for Research on Cancer, 2017.
[2] ANDERSON J R, ARMITAGE J O, WEISENBURGER D D. Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project[J]. Ann Oncol, 1998, 9(7):717-720.
[3] SAITO M, MORI A, TSUKAMOTO S, et al. Duodenal-type follicular lymphoma more than 10 years after treatment intervention: A retrospective single-center analysis[J]. World J Gastrointest Oncol, 2022, 14(8):1552-1561.
[4] TAKATA K, TANINO M, ENNISHI D, et al. Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis[J]. Cancer Sci, 2014, 105(5):608-615.
[5] SCHMATZ A I, STREUBEL B, KRETSCHMER-CHOTT E, et al. Primary follicular lymphoma of the duodenum is a distinct mucosal/submucosal variant of follicular lymphoma: a retrospective study of 63 cases[J]. J Clin Oncol, 2011, 29(11):1445-1451.
[6] TAKATA K, OKADA H, OHMIYA N, et al. Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: a multicenter, retrospective analysis in Japan[J]. Cancer Sci, 2011, 102(8):1532-1536.
[7] MORI M, KOBAYASHI Y, MAESHIMA A M, et al. The indolent course and high incidence of t(14;18) in primary duodenal follicular lymphoma[J]. Ann Oncol, 2010, 21(7):1500-1505.
[8] YOSHINO T, MIYAKE K, ICHIMURA K, et al. Increased incidence of follicular lymphoma in the duodenum[J]. Am J Surg Pathol, 2000, 24(5):688-693.
[9] SHIA J, TERUYA-FELDSTEIN J, PAN D, et al. Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases[J]. Am J Surg Pathol, 2002, 26(2):216-224.
[10] NAKAMURA S, MATSUMOTO T, UMENO J, et al. Endoscopic features of intestinal follicular lymphoma: the value of double-balloon enteroscopy[J]. Endoscopy, 2007, 39 Suppl 1:E26-E27.
[11] HIGUCHI N, SUMIDA Y, NAKAMURA K, et al. Impact of double-balloon endoscopy on the diagnosis of jejunoi-leal involvement in primary intestinal follicular lymphomas: a case series[J]. Endoscopy, 2009, 41(2):175-178.
[12] TAKATA K, SATO Y, NAKAMURA N, et al. Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics[J]. Mod Pathol, 2013, 26(1):22-31.
[13] TARI A, KITADAI Y, MOURI R, et al. Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma[J]. J Gastroenterol Hepatol, 2018, 33(8):1461-1468.
[14] MURAMATSU M, KINOSHITA K, FAGARASAN S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme[J]. Cell, 2000, 102(5):553- 563.
[15] LEUENBERGER M, FRIGERIO S, WILD P J, et al. AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations[J]. Mod Pathol, 2010, 23(2):177-186.
[16] MUTO A, TASHIRO S, NAKAJIMA O, et al. The transcriptional programme of antibody class switching involves the repressor Bach2[J]. Nature, 2004, 429(6991):566-571.
[17] SAKANE-ISHIKAWA E, NAKATSUKA S, TOMITA Y, et al. Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group[J]. J Clin Oncol, 2005, 23(31):8012-8017.
[18] TAKATA K, SATO Y, NAKAMURA N, et al. Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations[J]. Mod Pathol, 2009, 22(7):940-949.
[19] MAMESSIER E, SONG J Y, EBERLE F C, et al. Early lesions of follicular lymphoma: a genetic perspective[J]. Haematologica, 2014, 99(3):481-488.
[20] HELLMUTH J C, LOUISSAINT A JR, SZCZEPANOWSKI M, et al. Duodenal-type and nodal follicular lymphomas differ by their immune microenvironment rather than their mutation profiles[J]. Blood, 2018, 132(16):1695-1702.
[21] KAMIJO K, SHIMOMURA Y, YOSHIOKA S, et al. Clinical features and outcomes of duodenal-type follicular lymphoma: A single-center retrospective study[J]. EJHaem, 2022, 3(2):379-384.
[22] 陈青, 张燕林, 何妙侠, 等. 十二指肠型滤泡性淋巴瘤22例回顾性分析[J]. 临床与实验病理学杂志, 2019, 35(9):1112-1114.
[22] CHEN Q, ZHANG Y L, HE M X, et al. Duodenal-type Follicular Lymphoma: A Retrospective Study of 22 Cases[J]. J Clin Exp Pathol, 2019, 35(9): 1112-1114.
[23] TANIGAWA T, ABE R, KATO J, et al. Histological transformation in duodenal-type follicular lymphoma: a case report and review of the literature[J]. Oncotarget, 2019, 10(36):3424-3429.
[24] SENTANI K, MAESHIMA A M, NOMOTO J, et al. Follicular lymphoma of the duodenum: a clinicopathologic analysis of 26 cases[J]. Jpn J Clin Oncol, 2008, 38(8):547-552.
[25] KITABATAKE H, NAGAYA T, TANAKA N, et al. Development of diffuse large B-cell lymphoma from follicular lymphoma of the duodenum: changes in endoscopic findings during a 6-year follow-up[J]. Clin J Gastroenterol, 2017, 10(1):79-85.
[26] AKIYAMA S, IZUTSU K, OTA Y, et al. A case report of the histologic transformation of primary follicular lymphoma of the duodenum[J]. Medicine (Baltimore), 2014, 93(26):e165.
[27] HANGAI S, NAKAMURA F, KAMIKUBO Y, et al. Primary gastrointestinal follicular lymphoma with histological transformation[J]. Ann Hematol, 2013, 92(7):993-994.
[28] MIYATA-TAKATA T, TAKATA K, SATO Y, et al. A case of diffuse large B-cell lymphoma transformed from primary duodenal follicular lymphoma[J]. Pathol Int, 2014, 64(10):527-532.
[29] SABURI M, KONDO Y, OGATA M, et al. Development of diffuse large B-cell lymphoma from duodenal type follicular lymphoma: a retrospective study of 23 cases[J]. Int J Hematol, 2020, 112(5):658-665.
[30] TARI A, ASAOKU H, TAKATA K, et al. The role of “watch and wait” in intestinal follicular lymphoma in rituximab era[J]. Scand J Gastroenterol, 2016, 51(3):321- 328.
文章导航

/