诊断学理论与实践

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2025 , Vol. 24 >Issue 05: 465 - 470

DOI: https://doi.org/10.16150/j.1671-2870.2025.05.001

专家论坛

经导管去肾神经治疗高血压：现状与挑战

  • 姜凯文 ,
  • 董徽 ,
  • 蒋雄京
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  • 中国医学科学院北京协和医学院，国家心血管病中心，阜外医院心内科，北京 100037
蒋雄京 E-mail：jiangxj103@163.com

收稿日期: 2025-07-09

  修回日期: 2025-07-30

  录用日期: 2025-09-24

  网络出版日期: 2025-10-25

基金资助

国家自然科学基金(81700440);中央高水平医院临床科研业务费(2024-GSP-TJ-14);中央高水平医院临床科研业务费(2023-GSP-QN-10);中国医学科学院医学与健康科技创新工程(2021-I2M-C&T-B-026);中国医学科学院医学与健康科技创新工程(2021-I2M-C&T-B-027)

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Renal denervation for treatment of hypertension： current status and challenges

  • JIANG Kaiwen ,
  • DONG Hui ,
  • JIANG Xiongjing
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  • Department of Cardiology, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China

Received date: 2025-07-09

  Revised date: 2025-07-30

  Accepted date: 2025-09-24

  Online published: 2025-10-25

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摘要

经导管去肾神经术（renal denervation， RDN）是治疗高血压的新技术，近十几年来其已取得了显著进展。本文回顾国内外RDN治疗高血压主要随机对照临床试验证据，深入探讨了RDN疗法现存的关键问题，包括如何建立患者精准筛选体系，优化肾神经消融技术和术中评估肾神经阻断标准，以及开展心血管硬终点获益的大规模长期随访等。

关键词： 经导管去肾神经术; 高血压; 治疗

本文引用格式

姜凯文 , 董徽 , 蒋雄京 . 经导管去肾神经治疗高血压：现状与挑战[J]. 诊断学理论与实践, 2025 , 24(05) : 465 -470 . DOI: 10.16150/j.1671-2870.2025.05.001

Abstract

Renal denervation (RDN) represents a novel therapeutic approach for hypertension and has made significant progress over the past decade. This study reviews the main evidence from domestic and international randomized controlled clinical trials of RDN for hypertension treatment and provides an in-depth exploration of the critical unresolved issues in RDN therapy. These include how to establish precise patient selection systems, optimize renal nerve ablation techniques and intraoperative evaluation standards for denervation efficacy, and conduct large-scale, long-term follow-up stu-dies to evaluate benefits on cardiovascular hard endpoints.

Key words： Renal denervation; Hypertension; Therapy

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