目的: 研究上海地区居民胆囊结石病（以下简称胆石病）的患病情况及其相关的危险因素。方法: 2010年8月至2011年7月期间,对上海三个区部分20~79岁自然人群15 256人进行横断面调查。其中男8 617人,女6 639人。使用问卷调查、体格检查和实验室生化分析等方法收集参加者相关临床数据。胆囊疾病采用空腹B超检查确诊。采用t检验和Logistic逐步回归分析与胆石病相关的危险因素。结果: ①胆石病总体患病率为7.02%,女性（8.10%）略高于男性（6.19%）（P<0.05）。不论性别,胆石病的患病率随年龄递增（P<0.05）。②胆囊总体切除率为2.48%,女性（3.42%）是男性（1.75%）的约2倍（P<0.05）,也随年龄递增（P<0.05）。③Logistic逐步回归分析显示,女性、高龄、脂肪肝、胆石病家族史、高血压、体质量指数增加为胆石病相关的危险因素。结论: 本研究调查显示,当前上海地区人群总体胆石病患病率为7.02%,胆囊切除率为2.48%。性别、年龄、脂肪肝、胆石病家族史、高血压和体质量指数与胆石病发生密切相关。
Objective: To investigate the prevalence of gallbladder stone disease(GSD) in Shanghai and analyze the risk factors associated with GSD. Methods: The cross-section survey was carried out from August 2010 to July 2011. We enrolled 15 256 habitants in three districts of Shanghai (8 617 male and 6 639 female), aged between 20-79 years old. The relevant clinical data of the subjects were collected by questionnaire, physical examination and biochemical analysis. GSD was diagnosed by type-B ultrasonography. T test and Logistic stepwise regression were performed to analyze the risk factors associated with GSD. Results: ① The prevalence of GSD was 7.02% in this survey, which was slight higher in females than in males (8.10% vs 6.19%, P<0.05) and increased with age (P<0.05). ② The rate of cholecystectomy was 2.48% in total, almost twice in females than in males (3.42% vs 1.75%, P<0.05), and increased with age as well (P<0.05). ③ Logistic stepwise regression analysis showed that female, older, presence of fatty liver disease, family history, hypertension and increased body mass index (BMI) were the risk factors for GSD. Conclusions: Our survey showed that the prevalence of GSD was 7.02% and the cholecystectomy rate was 2.48% in Shanghai population. Gender, age, fatty liver disease, family history, hypertension and BMI were the risk factors associated with GSD.
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