[1] Chen W, Sun K, Zheng R, et al.Cancer incidence and mortality in China, 2014[J]. Chin J Cancer Res,2018,30(1):1-12.
[2] Chen W, Zheng R, Baade PD, et al.Cancer statistics in China, 2015[J]. Ca Cancer J Clin,2016,66(2):115-132.
[3] McGuigan A, Kelly P, Turkington RC, et al. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes[J]. World J Gastroenterol,2018, 24(43):4846-4861.
[4] Lankadasari MB, Mukhopadhyay P, Mohammed S, et al.TAMing pancreatic cancer: combat with a double edged sword[J]. Mol Cancer,2019,18(1):48.
[5] Yang MC, Wang HC, Hou YC, et al.Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine[J]. Mol Cancer,2015,14:179.
[6] Mizushima N.Autophagy: process and function[J]. Genes Dev,2007,21(22):2861-2873.
[7] Mizushima N, Levine B, Cuervo AM, et al.Autophagy fights disease through cellular self-digestion[J]. Nature,2008,451(7182):1069-1075.
[8] Yang A, Herter-Sprie G, Zhang H, et al.Autophagy sustains pancreatic cancer growth through both cell-autonomous and nonautonomous mechanisms[J]. Cancer Discov,2018,8(3):276-287.
[9] Yang A, Rajeshkumar NV, Wang X, et al.Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations[J]. Cancer Discov,2014,4(8):905-913.
[10] Yang S, Wang X, Contino G, et al.Pancreatic cancers require autophagy for tumor growth[J]. Genes Dev,2011, 25(7):717-729.
[11] Bachem MG, Schünemann M, Ramadani M, et al.Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells[J]. Gastroenterology,2005,128(4):907-921.
[12] Endo S, Nakata K, Ohuchida K, et al.Autophagy is required for activation of pancreatic stellate cells, associa-ted with pancreatic cancer progression and promotes growth of pancreatic tumors in mice[J]. Gastroenterology,2017,152(6):1492-1506.
[13] Sousa CM, Biancur DE, Wang X, et al.Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion[J]. Nature,2016,536(7617):479-483.
[14] Li X, Truty MA, Kang Y, et al.Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery[J]. Clin Cancer Res,2014,20(24):6529-6540.
[15] Ishiwata T, Cho K, Kawahara K, et al.Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer[J]. Oncol Rep,2007,18(3):537-543.
[16] Li X, Lee Y, Kang Y, et al.Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma[J] .Cell Death Differ,2019,26(2):382-393.
[17] Nielsen MF, Mortensen MB, Detlefsen S.Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells[J]. World J Gastroenterol,2016,22(9):2678-2700.
[18] Tao S, Lu H, Hong J, et al.Loss of stromal caveolin-1 expression: a novel tumor microenvironment biomarker that can predict poor clinical outcomes for pancreatic cancer[J]. PLoS One,2014,9(6):e97239.
[19] Pavlides S, Tsirigos A, Migneco G, et al.The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism[J]. Cell Cycle,2010,9(17):3485-3505.
[20] Guo JY, Chen HY, Mathew R, et al.Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis[J]. Genes Dev,2011,25(5):460-470.
[21] Zhang X, Schönrogge M, Eichberg J, et al.Blocking autophagy in cancer-associated fibroblasts supports chemotherapy of pancreatic cancer cells[J]. Front Oncol,2018,8:590.
[22] Fujii S, Mitsunaga S, Yamazaki M, et al.Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome[J]. Cancer Sci,2008,99(9):1813-1819.
[23] Jones S, Zhang X, Parsons DW, et al.Core signaling pathways in human pancreatic cancers revealed by global genomic analyses[J] .Science,2008,321(5897):1801-1806.
[24] Morris JP 4th, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma[J]. Nat Rev Cancer,2010,10(10):683-695.
[25] Furukawa T, Sunamura M, Horii A.Molecular mechanisms of pancreatic carcinogenesis[J]. Cancer Sci,2006, 97(1):1-7.
[26] Wang F, Xia X, Yang C, et al.SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy[J]. Clin Cancer Res,2018, 24(13):3176-3185.
[27] Liu Y, Chen C, Xu Z.Deletions linked to TP53 loss drive cancer through p53-independent mechanisms[J]. Nature,2016,531(7595):471-475.
[28] Rosenfeldt MT, O'Prey J, Morton JP, et al. p53 status determines the role of autophagy in pancreatic tumour development[J]. Nature,2013,504(7479):296-300.
[29] Rosenfeldt MT, O'Prey J, Flossbach L, et al. PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy[J]. Cell Death Differ,2017,24(7):1303-1304.
[30] 中国抗癌协会胰腺癌专业委员会. 胰腺癌综合诊治指南(2018版)[J]. 临床肝胆病杂志,2018,34(10):2109-2120.
[31] Mukubou H, Tsujimura T, Sasaki R, et al.The role of autophagy in the treatment of pancreatic cancer with gem-citabine and ionizing radiation[J]. Int J Oncol,2010,37(4):821-828.
[32] Wang P, Zhang J, Zhang L, et al.MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells[J]. Gastroenterology,2013,145(5):1133-1143.
[33] Wu C, Yang L, Qi X, et al.Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer[J]. 2018,Cancer Manag Res,2018,10:5261-5271.
[34] Li Q, Feng Y, Chao X, et al. HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b/MAPK1 axis[J]. Biosci Rep,2018,38(1):pii:BSR20171563.
[35] Pardo R, Lo Ré A, Archange C, et al.Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells[J]. Pancreatology,2010,10(1):19-26.
[36] Donadelli M, Dando I, Zaniboni T, et al.Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism[J]. Cell Death Dis,2011,2(4):e152.
[37] Andrej U, Andreas K, Stefan E, et al.Omeprazole inhibits proliferation and modulates autophagy in pancrea-tic cancer cells[J]. PLoS One,2011,6(5):e20143.
[38] Lund K, Olsen CE, Wong JJW, et al.5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin[J]. J Exp Clin Cancer Res,2017,36(1):187.
[39] 付志平, 杨卫平, 李科, 等. 自噬在吉西他滨诱导胰腺癌细胞凋亡中的作用[J]. 外科理论与实践,2014,19(4):329-334.
[40] Kinsey CG, Camolotto SA, Boespflug AM, et al.Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers[J]. Nat Med,2019,25(4):620-627.
[41] Bryant KL, Stalnecker CA, Zeitouni D, et al.Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer[J]. Nat Med,2019,25(4):628-640.
[42] Maycotte P, Gearheart CM, Barnard R, et al.STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious[J]. Cancer Res,2014,74(9):2579-2590.
[43] Gu J, Saiyin H, Fu D, et al.Stroma - a double-edged sword in pancreatic cancer: a lesson from targeting stroma in pancreatic cancer with Hedgehog signaling inhibitors[J]. Pancreas,2018,47(4):382-389.
[44] Sathiyaseelan P, Rothe K, Yang KC, et al.Diverse me-chanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?[J]. Autophagy,2019,15(2):368-371.