倾向评分匹配分析机器人中低位直肠癌根治术的泌尿功能保护作用
Effect of robotic surgery on urinary function following radical resection for middle and low rectal cancer: a propensity score matching analysis
Received date: 2019-12-09
Online published: 2020-05-25
目的:比较机器人与腹腔镜中低位直肠癌根治术病人的围术期相关指标及术后泌尿功能评分,评价机器人手术安全性及术后泌尿功能恢复情况。方法:回顾性分析2015年9月至2018年10月间在我科接受中低位直肠癌根治术313例病人的临床病理资料。运用倾向性评分匹配法(1∶1,卡钳值=0.01),基于性别、年龄、体质量指数、ASA评分和肿瘤分期,将机器人手术组与腹腔镜组配对。分析两种手术方式中低位直肠癌根治术的安全性以及对泌尿功能的影响。通过国际前列腺症状评分(IPSS)评估术前及术后1、3和6个月的泌尿功能。结果:倾向性评分配比后,两组各101例纳入配对研究。在手术根治度方面两组差异无统计学意义。两组在手术时间、术中出血量、术后首次排气时间、术后住院时间之间差异都有统计学意义(P<0.001)。机器人组IPSS在术后1个月低于腹腔镜组(P<0.001)。亚组分析显示,>60岁的低位直肠癌病人中,机器人组IPSS在术后1个月低于腹腔镜组(P=0.027)。术后3、6个月两组IPSS差异无统计学意义。结论:机器人手术的根治度与腹腔镜手术相仿。机器人直肠癌根治术后近期泌尿功能恢复以及康复都早于腹腔镜组,尤其在60岁以上的低位直肠癌病人中更为突出。
张雅琦, 张弢, 宋子甲, 顾一非, 彭毅, 季晓频, 赵任 . 倾向评分匹配分析机器人中低位直肠癌根治术的泌尿功能保护作用[J]. 外科理论与实践, 2020 , 25(03) : 245 -251 . DOI: 10.16139/j.1007-9610.2020.03.014
Objective To compare perioperative index and postoperative urinary function following radical resection for middle and low rectal cancer between robotic and laparoscopic surgery. Methods Clinicopathological data of 313 patients with radical surgery for middle and low rectal cancer at our department from September 2015 to October 2018 were analyzed retrospectively. Propensity score matching analysis (1∶1, caliper value=0.01) between robotic surgery group and laparoscopic surgery group was performed based on gender, age, body mass index, American Society of Anesthesiology score, and tumor staging. Two surgical approaches were studied for safety in radical treatment of middle and low rectal cancer and the effect on urinary function, which was assessed using the International Prostate Symptom Score (IPSS) preope-ratively and 1, 3, and 6 months after surgery. Results The matched sample of 101 cases in two groups using propensity score was included. There was no statistical difference in the outcome of radical resection between two groups. However, significant differences were found in operative time, intraoperative blood loss, time to first flatus and postoperative hospital stay (P<0.001). IPSS of robotic surgery group was significantly lower than that of laparoscopic group 1 month after surgery(P<0.001). IPSS of patients older than 60 with low rectal cancer in robotic surgery group was lower than that in laparoscopic surgery group 1 month postoperatively(P=0.027), and no significant difference in IPSS 3 and 6 months after surgery was present between two groups. Conclusions The efficacy of robotic radical surgery was same as laparoscopic surgery for middle and low rectal cancer. The radical surgery of patients with rectal cancer in robotic approach had urinary function less impaired and short-term rehabilitation better compared to that in laparoscopic approach, especially for patients older than 60 with low rectal cancer.
| [1] | Dulskas A, Miliauskas P, Tikuisis R, et al. The functio-nal results of radical rectal cancer surgery: review of the literature[J]. Acta Chir Belg, 2016, 116(1):1-10. |
| [2] | Liu Z, Huang M, Kang L, et al. Prognosis and postoperative genital function of function-preservative surgery of pelvic autonomic nerve preservation for male rectal cancer patients[J]. BMC Surg, 2016, 16:12. |
| [3] | 杨阳, 文刚. 中低位直肠癌保留盆腔自主神经对泌尿生殖功能的研究进展[J]. 世界最新医学信息文摘, 2018, 18(28):66-68. |
| [4] | 高庆坤, 牛鹏飞, 王延召, 等. 3D腹腔镜与开腹直肠癌根治术对男性性功能及泌尿功能的影响[J]. 中华临床医师杂志(电子版), 2019, 13(4):246-253. |
| [5] | 施毅卿, 刘坤, 李军, 等. 腹腔镜直肠癌全系膜切除术后排尿和性功能的评价[J]. 临床和实验医学杂志, 2018, 17(21):2314-2317. |
| [6] | Pedziwiatr M, Malczak P, Mizera M, et al. There is no difference in outcome between laparoscopic and open surgery for rectal cancer: a systematic review and meta-analysis on short- and long-term oncologic outcomes[J]. Tech Coloproctol, 2017, 21(8):595-604. |
| [7] | Yamaguchi T, Kinugasa Y, Shiomi A, et al. conventional laparoscopic surgery for rectal cancer: short-term outcomes at a single center[J]. Surg Today, 2016, 46(8):957-962. |
| [8] | Stănciulea O, Eftimie M, David L, et al. Robotic surgery for rectal cancer: a single center experience of 100 consecutive cases[J]. Chirurgia(Bucur), 2013, 108(2):143-151. |
| [9] | 王晓辉, 周力, 李小军, 等. 不同部位直肠癌的临床病理特点及预后分析[J]. 中国普通外科杂志, 2016, 25(8):1224-1228. |
| [10] | Morino M, Parini U, Allaix ME, et al. Male sexual and urinary function after laparoscopic total mesorectal excision[J]. Surg,Endosc, 2009, 23(6):1233-1240. |
| [11] | Batista-Miranda JE, Regalado Pareja, Huguet Prez J, et al. The use of the IPSS questionnaire in surgical patients. International Prostatic Symptom Score[J]. Actas Urol Esp, 1995, 19(3):227-233. |
| [12] | Hsiao SM, Lin HH, Kuo HC. International prostate symptom score for assessing lower urinary tract dysfunction in women[J]. Int Urogynecol J, 2013, 24(2):263-267. |
| [13] | Bolliger M, Kroehnert JA, Molineus F, et al. Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients[J]. Eur Surg, 2018, 50(6):256-261. |
| [14] | Okamura K, Nojiri Y, Osuga Y, et al. Psychometric analysis of international prostate symptom score for female lower urinary tract symptoms[J]. Urology, 2009, 73(6):1199-1202. |
| [15] | Panteleimonitis S, Ahmed J, Harper M, et al. Critical analysis of the literature investigating urogenital function preservation following robotic rectal cancer surgery[J]. World J Gastrointest Surg, 2016, 8(11):744-754. |
| [16] | Moszkowicz D, Alsaid B, Bessede T, et al. Where does pelvic nerve injury occur during rectal surgery for cancer?[J]. Colorectal Dis, 2011, 13(12):1326-1334. |
| [17] | Kirkham AP, Mundy AR, Heald RJ, et al. Cadaveric dissection for the rectal surgeon[J]. Ann R Coll Surg Engl, 2001, 83(2):89-95. |
| [18] | 张策, 李国新, 丁自海, 等. 直肠癌外科与自主神经保留: 肠系膜下动脉结扎的神经解剖因素[J]. 南方医科大学学报, 2006, 26(1):49-52. |
| [19] | 施毅卿, 赵任. 中低位直肠癌术后尿生殖功能影响的评价[J]. 外科理论与实践, 2012, 17(2):184-186. |
| [20] | Cho MS, Baek SJ, Hur H, et al. Short and long-term outcomes of robotic versus laparoscopic total mesorectal excision for rectal cancer: a case-matched retrospective study[J]. Medicine (Baltimore), 2015, 94(11):e522. |
| [21] | Luca F, Valvo M, Ghezzi TL, et al. Impact of robotic surgery on sexual and urinary functions after fully robotic nerve-sparing total mesorectal excision for rectal cancer[J]. Ann Surg, 2013, 257(4):672-678. |
| [22] | Luca F, Craigg DK, Senthil M, et al. Sexual and urinary outcomes in robotic rectal surgery: review of the literature and technical considerations[J]. Updates Surg, 2018, 70(3):415-421. |
| [23] | Li X, Wang T, Yao L, et al. The safety and effectiveness of robot-assisted versus laparoscopic TME in patients with rectal cancer: A meta-analysis and systematic review[J]. Medicine (Baltimore), 2017, 96(29):e7585. |
| [24] | Law WL, Foo DCC. Comparison of short-term and oncologic outcomes of robotic and laparoscopic resection for mid- and distal rectal cancer[J]. Surg Endosc, 2017, 31(7):2798-2807. |
| [25] | Kim MJ, Park SC, Park JW, et al. Robot-assisted versus laparoscopic surgery for rectal cancer: a phase Ⅱ open label prospective randomized controlled trial[J]. Ann Surg, 2018, 267(2):243-251. |
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