外科理论与实践

外科理论与实践 >

2022 , Vol. 27 >Issue 02: 180 - 184

DOI: https://doi.org/10.16139/j.1007-9610.2022.02.018

综述

肝细胞癌肺转移的潜在机制和治疗进展

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  • 1.天津医科大学肿瘤医院肝胆肿瘤科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室,天津 300060
    2.复旦大学附属肿瘤医院肝脏外科,上海 200032

收稿日期: 2022-03-15

  网络出版日期: 2022-06-16

基金资助

国家自然科学基金(82172632)

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Pulmonary metastasis of hepatocellular carcinoma: pathogenesis and therapeutic advances

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  • 1. Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, National Cancer Clinical Research Center, Tianjin 300060, China
    2. Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China

Received date: 2022-03-15

  Online published: 2022-06-16

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摘要

近年来, 随着肝细胞癌（hepatocellular carcinoma, HCC）诊疗方法的不断丰富和改进, 病人生存得到改善。但远处转移的发生率逐渐上升,影响HCC病人的总体预后。肺是HCC远处转移的最常见器官。由于个体差异和肿瘤异质性,HCC肺转移疗效仍令人失望, 中位总生存期少于1年。目前尚无HCC肺转移标准治疗的规范,临床医师通常结合晚期HCC和肺癌的治疗指南对HCC肺转移病人进行治疗。尽管过去几十年关于HCC侵袭转移的研究层出不穷,但肺转移详细机制尚不明确。本文回顾HCC肺转移机制的研究及其治疗的进展,显示肝内病灶控制和肺转移灶处理的重要性。

关键词： 肝细胞癌; 肺转移; 肿瘤微环境

本文引用格式

管涛(综述), 张倜, 王鲁(审校) . 肝细胞癌肺转移的潜在机制和治疗进展[J]. 外科理论与实践, 2022 , 27(02) : 180 -184 . DOI: 10.16139/j.1007-9610.2022.02.018

Abstract

In recent years, the survival of patients increased with development of treatment modalities for hepatocellular carcinoma(HCC). However, the incidence of distant metastasis was gradually increasing to make the prognosis of patients with HCC worse. Lungs are the most common distant metastatic organs from HCC. Therapy of pulmonary metastasis from HCC was still disappointing with the median overall survival less than 1 year for individual differences in patients and tumor heterogeneity. Currently, there was without standard treatment for pulmonary metastases from HCC, and the patients were treated according to the treatment guidelines of advanced HCC combined with lung cancer. Although studies on invasion and metastasis of HCC emerged in a few decades, the detail pathogenesis of lung metastasis remains unclear. This article will summarize the pathogenesis and therapeutic advances of pulmonary metastasis from HCC and emphasize the importance of intrahepatic lesion control and management of pulmonary metastases.

Key words： Hepatocellular carcinoma; pulmonary metastasis; Tumor microenvironment

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