目的：探讨内镜逆行胰胆管造影术（endoscopic retrograde cholangiopancreatography,ERCP）诊治胰胆汇合异常（pancreaticobiliary maljunction, PBM）的疗效及安全性。方法：收集浙江大学医学院附属杭州市第一人民医院2007年12月至2020年8月经ERCP诊治的PBM病人,分析PBM临床表现、ERCP治疗、术后并发症发生情况。结果：共检出219例PBM病人,男95例,女124例,平均年龄（52.11±23.32）（2~89）岁。术前以腹痛为主要临床表现（77.93%）。ERCP插管成功率为98.17%（215/219）,治疗缓解率为96.80%（212/219）。共23例次（7.93%）出现术后并发症,均经保守治疗痊愈。结论：PBM女性略多于男性,腹痛为主要症状。 经ERCP治疗PBM引发的胆胰疾病疗效良好且安全性高。

Objective To investigate the effect and safety of endoscopic retrograde cholangiopancreatography (ERCP) in the diagnosis and treatment of pancreaticobiliary maljunction (PBM). Methods The patients with PBM were diagnosed and treated using ERCP and included from December 2007 to August 2020 in Hangzhou First People's Hospital of Zhejiang University School of Medicine. The clinical manifestations of PBM, ERCP treatment, and post ERCP complications were analyzed. Results A total of 219 patients with PBM were in this study including 95 males and 124 females with an average age of (52.11±23.32) (2-89) years. Abdominal pain (77.93%) was the main clinical manifestations of PBM. The success rate of endoscopy intubation was 98.17% (215/219), and the cases with curative ERCP was 96.80% (212/219). Twenty-three of ERCP(7.93%) had post ERCP complications cured all by conservative treatment. Conclusions PBM is more common in women with main manifestation of abdominal pain. ERCP is effective and safe for biliary and pancreatic diseases induced by PBM.