目的：研究内镜全层切除术治疗胃黏膜下小肿瘤（直径≤1 cm）的临床效果。方法：回顾性分析2015年1月至12月本院行内镜全层切除术治疗胃黏膜下小肿瘤的102例病人,观察肿瘤切除率、手术时间、术中出血、术后并发症发生情况。术后内镜随访,评价治疗效果与安全性。结果：102例均成功完成内镜治疗,肿瘤完整切除,平均手术时间（34.8±7.5）（11~126） min。病理检查结果肿瘤直径为（0.50±0.36）（0.3~1.0） cm,肿瘤均位于胃底。病理检查结果为,间质瘤51例（50.0%）,平滑肌瘤45例（44.1%）,纤维瘤2例（2.0%）,神经内分泌肿瘤2例（2.0%）,错构瘤1例（1.0%）,淋巴瘤1例（1.0%）。所有病人均未发生出血及穿孔。术后随访期间所有病例胃创面愈合良好。结论：应用内镜全层切除术治疗胃黏膜下小肿瘤是安全、有效的。

Objective To evaluate the clinical efficacy of endoscopic full thickness resection in treatment of small gastric submucosal tumors (diameter≤1 cm). Methods A total of 102 patients with small gastric submucosal tumors treated using endoscopic full thickness resection in Zhongshan Hospital, Fudan University between January 2015 and December 2015 were analyzed retrospectively. Tumor resection rate, procedure time, interoperative bleeding and postoperative complications were observed in the procedures. Patients had follow-up endoscopy for evaluation of efficacy and safety. Results Endoscopic treatment was successful and resection of tumor was complete for all 102 patients. The average procedure time was (34.8±7.5) (11-126) min, Tumor diameter was (0.50±0.36) (0.3-1.0) cm and located all at gastric fundus. Pathological diagnose showed that 51 cases were with stromal tumor(50%), 45 cases with leiomyoma(44.1%), 2 cases with fibroma (2.0%), 2 cases with neuroendocrine tumors(2.0%), 1 case with hamartoma(1.0%), and 1 case with lymphoma(1.0%). Bleeding and perforation were not found and lesion surface of stomach was repaired well shown by follow-up. Conclusions Endoscopic full thickness resection in treatment of gastric submucosal tumors is effective and safe.