肥胖与早期乳腺癌预后和辅助治疗疗效的研究进展
Study on obesity associated with prognosis of early breast cancer and efficacy of adjuvant therapy
Received date: 2021-04-06
Online published: 2022-11-10
朱思毅 综述, 陈小松, 沈坤炜 审校 . 肥胖与早期乳腺癌预后和辅助治疗疗效的研究进展[J]. 外科理论与实践, 2022 , 27(05) : 468 -472 . DOI: 10.16139/j.1007-9610.2022.05.017
With overweight and obese population increasing worldwide, the association of body mass index(BMI) of breast cancer patients with the prognosis and treatment efficacy has become a hot topic. Here we reviewed the impact of obesity on prognosis and efficacy of adjuvant therapy of early breast cancer. A number of studies have shown that higher BMI was associated with larger tumors and increased lymph node involvement, more grading and higher proliferation. The effect of obesity on prognosis of early breast cancer differed across disease subtypes. Obesity was associated with poorer prognosis for hormone receptor-positive breast cancer, while the association of obesity with prognosis for other breast cancer subtypes was still controversial. Obesity could probably decrease the efficacy of adjuvant lipophilic chemotherapies for early breast cancer. The impact of obesity on efficacy of adjuvant endocrine therapy might depend on the type of aromatase inhibitor. The correlation between obesity and efficacy of adjuvant HER2- targeted therapy has not been clear.
Key words： Breast cancer; Obesity; Adjuvant therapy
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