外科理论与实践

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2023 , Vol. 28 >Issue 06: 524 - 528

DOI: https://doi.org/10.16139/j.1007-9610.2023.06.07

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高细胞亚型甲状腺乳头状癌的侵袭性组织病理学特征研究

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  • 上海交通大学医学院附属瑞金医院普外科，上海 200025

收稿日期: 2023-09-18

  网络出版日期: 2024-03-04

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Study on invasive histopathological features of papillary thyroid carcinoma with tall cell variant

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  • Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2023-09-18

  Online published: 2024-03-04

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摘要

目的: 探索研究高细胞亚型(tall cell variant, TCV)甲状腺乳头状癌(papillary thyroid carcinoma, PTC)的侵袭性组织病理学特征。方法: 回顾性分析2018年1月至2023年5月上海交通大学医学院附属瑞金医院19 170例PTC病例，分析比较TCV-PTC组和经典型PTC(classic PTC, cPTC)组的临床病理学特征。结果: 病理结果显示TCV-PTC组1 380例，cPTC组15 578例。TCV-PTC在病人年龄以及肿瘤腺外侵犯、神经侵犯、脉管侵犯、癌灶最大径、多灶癌、中央区和颈侧区淋巴结转移和BRAF基因突变比例和（或）均值均较高，但合并桥本甲状腺炎的比例少于cPTC，差异有统计学意义（P<0.05）。结论: TCV-PTC与cPTC相比，局部侵袭性特征较强和淋巴结转移率较高，该病理类型的判定为后续更积极的临床治疗选择提供依据。

关键词： 甲状腺乳头状癌; 高细胞亚型; 病理学特征; 肿瘤侵袭和转移

本文引用格式

廖振宇, 赵起悟, 匡洁, 刘卓然, 孙寒星, 王越, 邱伟华, 陈曦, 严佶祺 . 高细胞亚型甲状腺乳头状癌的侵袭性组织病理学特征研究[J]. 外科理论与实践, 2023 , 28(06) : 524 -528 . DOI: 10.16139/j.1007-9610.2023.06.07

Abstract

Objective To study the invasive histopathological features of papillary thyroid carcinoma(PTC) with tall cell variant(TCV). Methods A retrospective analysis of 19 170 cases of PTC in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from January 2018 to May 2023 was performed to analyze and the clinicopathological features between TCV-PTC group and classic PTC (cPTC) group. Results Pathological results showed 1 380 cases in TCV-PTC group and 15 578 cases in cPTC group. TCV-PTC had higher proportion and (or) mean value in patients' age, extraglandular invasion, nerve invasion, vascular invasion, maximum diameter of cancer focus, multifocality，lymph node metastasis and BRAF mutation, but the proportion of patients with coexistent Hashimoto's thyroiditis was lower than cPTC， and all results had significant difference (P<0.05). Conclusions Compared with the cPTC, TCV-PTC has stronger local invasive characteristics and lymph node metastasis rate, which provides the basis for the subsequent clinical treatment.

Key words： Papillary thyroid carcinoma; Tall cell variant; Histopathological feature; Tumor invasion and metastasis

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