外科理论与实践

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2025 , Vol. 30 >Issue 2: 93 - 100

DOI: https://doi.org/10.16139/j.1007-9610.2025.02.01

专家论坛

晚期胆管癌系统治疗：全球指南的分歧与区域临床实践

  • 李淳 ,
  • 马祖燚 ,
  • 孙嘉 ,
  • 李秉璐
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  • 中国医学科学院北京协和医院基本外科，北京 100005
李秉璐，E-mail: PUMCHLBL@163.com

收稿日期: 2025-02-16

  网络出版日期: 2025-07-07

基金资助

中国医学基金会“临床医学科研促进计划”(2025CMFA08)

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Systemic therapy for advanced cholangiocarcinoma: divergences in global guidelines and regional clinical implementation

  • LI Chun ,
  • MA Zuyi ,
  • SUN Jia ,
  • LI Binglu
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  • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005， China

Received date: 2025-02-16

  Online published: 2025-07-07

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摘要

胆管癌（CCA）是一类起源于胆道上皮的恶性肿瘤，晚期病人多以系统治疗为主。近年来，其分子分型及靶向治疗研究快速发展，推动胆管癌相关治疗指南的快速更新。本文主要针对晚期CCA的系统治疗方案进展以及国内外指南的相关推荐展开综述，旨在为CCA病人的临床管理和决策制定提供更多的循证医学证据。

关键词： 胆管癌; 系统治疗; 化疗; 免疫治疗; 分子靶向治疗

本文引用格式

李淳 , 马祖燚 , 孙嘉 , 李秉璐 . 晚期胆管癌系统治疗：全球指南的分歧与区域临床实践[J]. 外科理论与实践, 2025 , 30(2) : 93 -100 . DOI: 10.16139/j.1007-9610.2025.02.01

Abstract

Cholangiocarcinoma (CCA) is a group of malignant tumors arising from the biliary epithelium, with systemic therapy serving as the primary treatment approach for patients with advanced disease. In recent years, advances in molecular classification and targeted therapy have led to rapid updates in treatment guidelines for CCA. This review summarized recent progress in systemic treatment strategies for advanced CCA and the relevant recommendations in both international and domestic guidelines, aiming to provide evidence-based references for clinical management and decision-making in patients with CCA.

Key words： Cholangiocarcinoma(CCA); Systemic therapy; Chemotherapy; Immunotherapy; Molecular targeted therapy

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