外科理论与实践

外科理论与实践 >

2025 , Vol. 30 >Issue 04: 351 - 357

DOI: https://doi.org/10.16139/j.1007-9610.2025.04.10

综述

循环肿瘤DNA检测微小残留病灶在结肠直肠癌肝转移中的应用进展

  • 李雅琪 ,
  • 莫少波 综述 ,
  • 彭俊杰 审校
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  • 复旦大学附属肿瘤医院大肠外二科 复旦大学上海医学院肿瘤学系，上海 200032

收稿日期: 2024-04-03

  网络出版日期: 2025-10-23

基金资助

国家自然科学基金(82473500);国家自然科学基金(82372974);国家自然科学基金(82203215);上海市科学技术委员会“扬帆计划”(22YF1408800)

收起

Progression in circulating tumor DNA detection for minimal residual disease in patients with colorectal cancer liver metastasis

  • LI Yaqi ,
  • MO Shaobo ,
  • PENG Junjie
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  • Department of Colorectal Surgery, Division Ⅱ, Fudan University Shanghai Cancer Center

Received date: 2024-04-03

  Online published: 2025-10-23

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摘要

循环肿瘤DNA(ctDNA)作为一种非侵入性生物标志物，能敏感地识别微小残留病灶(MRD)，可提早发现复发转移，为结肠直肠癌肝转移(CRLM)病人的预后预测和疗效评估提供了新方法，有助于指导个性化治疗方案的制定。本文归纳了ctDNA检测MRD在CRLM中的应用进展，并对其未来发展方向加以展望。

关键词： 结肠直肠癌肝转移; 循环肿瘤DNA; 微小残留病灶; 预后预测; 疗效评估

本文引用格式

李雅琪 , 莫少波 综述 , 彭俊杰 审校 . 循环肿瘤DNA检测微小残留病灶在结肠直肠癌肝转移中的应用进展[J]. 外科理论与实践, 2025 , 30(04) : 351 -357 . DOI: 10.16139/j.1007-9610.2025.04.10

Abstract

As a non-invasive biomarker, circulating tumor DNA (ctDNA) can sensitively identify minimal residual disease (MRD), offering a novel approach for prognosis prediction and efficacy evaluation in patients with colorectal cancer liver metastasis (CRLM), thereby aiding in the formulation of personalized treatment strategies. This article summarized the progress in the application of ctDNA detection for MRD in CRLM and provided insights into its future directions.

Key words： Colorectal cancer liver metastasis(CRLM); Circulating tumor DNA(ctDNA); Minimal residual disease(MRD); Prognostic prediction; Efficacy evaluation

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