组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2015, Vol. 11 ›› Issue (4): 266-268.doi: 10.3969/j.issn.1673-0364.2015.04.013

• 论著 • 上一篇    下一篇

不同分化阶段多能干细胞移植实验研究进展

李君，杜潇，周晓囡，吴嫣爽，雷蕾   

  1. 哈尔滨医科大学组织学与胚胎学教研室
  • 发布日期:2020-07-23

Transplantation Studies of Pluripotent Stem Cells at Different Differentiated Stages

LI Jun,DU Xiao,ZHOU Xiaonan,WU Yanshuang,LEI Lei   

  • Published:2020-07-23
  • Contact: 国家973项目(2012cba01303)

摘要： 诱导多能干细胞是由动物体细胞重编程得到的,具有胚胎干细胞特性的全能干细胞。近年来,随着多能干细胞诱导技术的不断优化,以及体外分化技术的飞速发展,多种分化状态的多能干细胞被用于移植实验。我们结合最新研究进展,阐述各种分化阶段i PS细胞用于动物移植治疗的优缺点,以及最新移植方法所存在的问题。

关键词: 诱导多能干细胞, 囊胚互补, 器官芽

Abstract: Induced pluripotent stem cells (iPSCs) derived from reprogrammed somatic cells, are totipotential cells similar to embryonic stem cells. Recently, iPSCs inducing technology has been promptly improved in methods of induction and differentiation in vitro. Consequently, iPSCs at different differentiated stages have been widely used in cell transplantation experiments. Here, the current researches of iPSCs transplantation were summarized, some novel methods comparing with the older one and some problems need to be resolved before iPSCs could be applied in clinic therapy were all reviewed.

Key words: Induced pluripotent stem cells, Blastocyst complementation, Organ bud

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