组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (1): 121-.

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利用生物打印技自下而上地设计生物组

  

  • 发布日期:2024-03-07

Designing biological tissues from the bottom-up using bioprinting technology

  • Published:2024-03-07

摘要:

 随着人们对组织和器官需求的不断增长,组织工程领域取得了长足的发展。然而,再造具有功能的组织和器
官仍然是一个巨大挑战。近些年,为了构建具有生理功能的组织,不少研究提出了“自下而上”的组织工程策略。该策
略主要包括两个关键步骤:模块化组织的构建和组织模块的组装。生物打印技术因其高度自动化、在高精度组织工程
方面的卓越能力以及构建多成分组织的潜力,在“自下而上”的组织构建研究中得到广泛应用。在本综述中,我们分别
总结了应用于模块化组织制造和组装的技术,特别阐述了“自下而上”生物打印的机制和应用,最后总结了“自下而上”
组织工程未来趋势,希望为该领域的研究人员提供有用的参考和灵感。

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Abstract:

】 The field of tissue engineering has grown considerably over the decades as the demand for tissues and organs
continues to grow. However, recreating functional tissues and organs is still a great challenge. In recent years, a number of
researchers have proposed a “bottom-up” tissue engineering strategy to construct physiologically functional tissues. This
strategy consists of two key steps: First, the construction of modular tissues, followed by the assembly of tissue modules.
Bioprinting technology has been widely used in “bottom-up” tissue construction studies due to its high degree of automation,
superior ability in high-precision tissue engineering, and potential for building multi-component tissues. In this review, the
technologies applied to modular tissue fabrication and assembly were summarized, with a special focus on the mechanisms
and applications of “bottom-up” bioprinting. Finally, the future trends of “bottom-up” tissue engineering were summarized,
hoping to provide useful references and inspirations for researchers in this field.

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