组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (2): 234-.

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组织工程骨移植物的血管化策略研究

  

  • 出版日期:2024-04-30 发布日期:2024-05-16

Research on vascularization strategy of bone tissue engineering graft

  • Online:2024-04-30 Published:2024-05-16

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摘要：

利用骨组织工程修复大段骨缺损是一种富有前景的方法。骨骼是动态的高度血管化组织，在适当时间内形成血管组织是保证骨移植物存活、修复、重塑的关键，也是骨组织工程的主要挑战之一。本文将从血管化的意义，以及基于种子细胞、促血管生成因子、支架结构、免疫调控、体外预血管化等策略来综述组织工程骨移植物血管化的研究进展

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Abstract:

Bone tissue engineering is a promising method for repairing large-scale bone defects. Bone is a dynamic and
highly vascularized tissue， and the formation of vascular tissue in an appropriate time is the key to ensure the survival， repair
and remodeling of bone graft， as well as one of the main challenges of bone tissue engineering. In this paper， the research
progress of vascularization of bone tissue engineering grafts from the perspective of the significance of vascularization and
strategies based on seed cells， angiogenic factors， scaffold structure， immune regulation， and prevascularization was
reviewed .

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