先天性黑素细胞痣的发病机制及诊疗策略

组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (2): 254-.

先天性黑素细胞痣的发病机制及诊疗策略

出版日期:2024-04-30 发布日期:2024-05-16

The pathogenesis and therapeutic strategies for congenital melanocytic nevi

Online:2024-04-30 Published:2024-05-16

摘要/Abstract

摘要：

先天性黑素细胞痣（Congenital melanocytic nevi，CMN）是一种常见的皮肤发育异常，可发生于人体任何有黑素细胞存在的部位。其发生与体细胞突变密切相关，受多种信号通路调控，临床表现多样。手术切除、扩张器应用仍是治疗CMN的主要方式，光电治疗是消除色素、清除卫星灶的有力手段。靶向、免疫治疗正成为治疗先天性黑色素巨痣的新方向。

关键词:

先天性黑素细胞痣, 　发病机制, 　体细胞突变, 　靶向治疗

Abstract:

Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the

body where melanocytes are present. Its occurrence is closely related to somatic cell mutations， regulated by multiple

signaling pathways， and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for

CMN， and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and

immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi.

Key words:

Congenital melanocytic nevus, Pathogenesis, Somatic mutation, Targeted therapy

李东东, 王斌. 先天性黑素细胞痣的发病机制及诊疗策略[J]. 组织工程与重建外科杂志, 2024, 20(2): 254-.

LI Dongdong, WANG Bin. The pathogenesis and therapeutic strategies for congenital melanocytic nevi[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2024, 20(2): 254-.