隆突性皮肤纤维肉瘤的分子生物学进展

组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (2): 260-.

隆突性皮肤纤维肉瘤的分子生物学进展

出版日期:2024-04-30 发布日期:2024-05-16

Advances in molecular genetics of dermatofibrosarcoma protuberans

Online:2024-04-30 Published:2024-05-16

摘要/Abstract

摘要：

　隆突性皮肤纤维肉瘤（Dermatofibrosarcoma protuberans，DFSP）是最常见的皮肤肉瘤之一，缺乏特异性临床和影像学表现，组织病理学复杂，以缓慢不规则浸润周围组织为生长特点，治疗以手术切除为主。目前，DFSP在临床上存在易误诊、漏诊率高和复发率高的难点，亟待开发出特异性的诊断标志物和有效的治疗靶点。本文将对DFSP的最新分子生物学进展进行综述，以期为该肿瘤的诊断和治疗提供新的思路。

关键词:

隆突性皮肤纤维肉瘤, 　分子生物学, 　重排, 　变异

Abstract:

Dermatofibrosarcoma protuberans （DFSP）， one of the most common skin sarcomas， lacks specific clinical

and radiological features and exhibits complex histopathology. It is characterized by slow and irregular infiltration of

surrounding tissues， and surgical resection is the primary treatment modality. Currently， DFSP presents clinical challenges in

terms of high misdiagnosis and recurrence rates， necessitating the development of specific diagnostic markers and effective

therapeutic targets. This article aimed to provide a comprehensive review of the latest molecular genetics advancements in

DFSP， with the goal of offering new insights for its diagnosis and treatment.

Key words:

Dermatofibrosarcoma protuberans, Molecular biology, Rearrangement, Mutation

邓雨琦, 梁筱, 孙笛, 等.

隆突性皮肤纤维肉瘤的分子生物学进展 [J]. 组织工程与重建外科杂志, 2024, 20(2): 260-.

DENG Yuqi, LIANG Xiao, SUN Di, et al.

Advances in molecular genetics of dermatofibrosarcoma protuberans [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2024, 20(2): 260-.