有限元, 　微结构, 3D打印, 　生物支架, 　细胞黏附, 　流体力学

Objective To study the influence of 3D-printed bone scaffolds with different pore morphologies on cell

adhesion. Methods Utilizing MSLattice software， four porous structures with different pore morphologies， namely cubic，

Hexagon， diamond， and gyroid， were designed. The principles of finite element analysis （FEM） and computational fluid

dynamics （CFD） were employed using Siemens Star CCM+ software to simulate the fluid flow within the four scaffold

structures， model the process of cell adhesion， measure the fluid flow velocity and pressure within the scaffold， as well as the

fluid permeability and the thickness of the adhesion layer. Results Upon the passage of fluid through the four types of

scaffolds， the pressure gradually diminished. However， due to the relatively regular structure of the scaffolds， the pressure

exhibited a gradient distribution. The simulated pressure values before fluid flow through the four types of scaffolds were， in

sequence： Gyroid>Cubic>Diamond>Hexagon. Flow velocity： Cubic>Gyroid>Diamond>Hexagon. The permeability of the four

types of scaffolds： Diamond>Hexagon>Cubic>Gyroid. Adhesion layer thickness： Gyroid>Hexagon>Cubic>Diamond.

Conclusion The fluid mechanics analysis results show that the gyroid scaffold has lower permeability and the highest

adhesion layer thickness， which is more conducive to cell adhesion.

Finite element, Microstructure, 3D printing, Biological scaffold, Cell adhesion, Fluid mechanics