关键词: 毛细血管畸形, &emsp, 葡萄酒色斑, &emsp, 新生儿红斑, &emsp, 脉冲染料激光, &emsp, 光动力治疗

Abstract: Objective To compare the efficacy of pulsed dye laser （PDL） in treating salmon patch （SP） and port-wine stain（ PWS） in V1 area. Methods A retrospective case-control study was conducted on 40 untreated patients（ 22 with SP， 18 with PWS in the V1 area）， who underwent 3 sessions of PDL treatment （spot size： 7 mm； fluence： 8-11 J/cm2 ； pulse duration： 0.45-1.5 ms）. Improvement in lesion color and size （graded 0-5） before and after treatment was evaluated using standardized photographs and visual analog scale（ VAS） scores， while adverse effects were recorded. Differences in efficacy were analyzed using the t-test. Results The mean VAS scores were significantly higher in SP patients than in PWS patients （color improvement： 3.68±1.13 vs. 1.44±1.38； size improvement： 3.36±1.26 vs. 1.22±1.17； P<0.01）. Significant improvement was achieved in SP after ≤3 treatments， and PWS was less effective after 3 treatments. Regarding safety， only one case of SP exhibited transient hyperpigmentation. Histological analysis revealed that the mean depth of SP vessels was （212.90±35.70） µm， significantly shallower than that of PWS （＞400 µm）， suggesting that PDL is more effective for superficial vessels. Conclusion PDL was significantly more effective for SP than for PWS， likely due to differences in vessel depth. 

Key words: Capillary malformation, &emsp, Port-wine stain, &emsp, Salmon patch, &emsp, Pulsed dye laser, &emsp, Photodynamic therapy