组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2011, Vol. 7 ›› Issue (1): 45-47.doi: 10.3969/j.issn.1673-0364.2011.01.013

• 论著 • 上一篇    下一篇

内源性一氧化氮合酶抑制剂与重编程功能性心肌干细胞

汪进益，范慧敏，刘中民   

  1. 同济大学附属东方医院胸心外科
  • 发布日期:2020-07-23

Endogenous Inhibitor of Nitric Oxide Synthase and Reprogramming Functional Cardiac Stem Cells

WANG Jinyi,FAN Huimin,LIU Zhongmin   

  1. Department of Cardiovascular and Thoracic Surgery,Shanghai East Hospital,Tongji University,Shanghai 200120,China.
  • Published:2020-07-23

摘要： 干细胞再生医学在器官组织修复中已凸现出非常重要的地位。通过外源性表达基因进行体细胞的重编程,是目前最有希望获得供移植细胞的方式。微环境对于移植细胞的存活、迁移、分化起决定性作用。内源性一氧化氮合酶抑制剂系统(ADMA/DDAH)不但在调控血管生成中起着关键性作用,而且对肌细胞的诱导分化和促进肌生成方面发挥重要作用。本文就ADMA/DDAH对重编程"功能性心肌细胞"的作用予以阐述。

关键词: 非对称型左旋二甲基精氨酸, 重编程, 功能性心肌干细胞, 成纤维细胞

Abstract: Stem cells regenerative medicine plays an important role in the repair of organ tissue and regeneration.By now,reprogramming of somatic cells through the exogenous genes is the most hopeful way to get transplant cells.Microenvironment is the most important factor in the survival,immigration,and differentiation of transplanted cells.Endogenous inhibitor of nitric oxide synthase system(ADMA/DDAH pathway) may plays a key role in regulating angiogenesis,inducing differentiation of muscle cells and promoting muscle generation by the DDAH/ADMA pathway regulation.

Key words: Asymmetric dimethylarginine, Reprogramming, Functional cardiomyocytes, Fibroblast

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