组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2010, Vol. 6 ›› Issue (5): 261-264.doi: 10.3969/j.issn.1673-0364.2010.05.006

• 论著 • 上一篇    下一篇

幼犬单侧牙槽突裂对上颌骨发育的影响

陈诚，吴丽丽，赵宇   

  1. 合肥市安徽医科大学第一附属医院整形美容外科
  • 发布日期:2020-07-23

Effects on Maxillary Growth in Unilateral Cleft Alveolar of Animal Model

CHEN Cheng, WU Lili, ZHAO Yu   

  1. Department of Plastic Surgery,First Affiliated Hospital of Anhui Medical University,Hefei 230022,China.Corresponding author: ZHAO Yu.
  • Published:2020-07-23
  • Contact: 安徽省临床医学重点学科新技术研究基金(2008D04)

摘要： 目的建立类似临床牙槽突裂的动物模型,研究单侧牙槽突裂在上颌骨快速发育期内对生长发育的影响。方法 7周龄家犬20只,随机分为实验组、对照组（n=10）,通过手术使实验组形成单侧牙槽突裂。术后12周,CT三维重建测量上颌骨发育指标,评价裂隙对上颌骨发育影响。结果实验组上颌骨前部及中部的长度和前部的宽度、高度与对照组相比,均存在发育异常,两组测量数值具有显著性差异（P<0.05）。结论未经早期修复的单侧牙槽突裂在上颌骨快速发育期内对生长发育具有一定影响。

关键词: 牙槽突, 犬, 上颌骨, 生长

Abstract: Objective To establish an animal model of unilateral alveolar cleft similar with clinical patients and study the effects on the growth of maxilla during the period of rapid development.Methods Twenty dogs（7 weeks old） were divided into the control group（n=10） and the experimental group（n=10）.The dogs experimental group were operated to create a unilateral alveolar cleft.The data of maxillofacial morphology such as the length,width and height of the foreside,middle and back of maxilla via three-dimensional reconstruction CT to evaluate the effects on the growth of maxilla 12 weeks were measured after operation.Results The foreside and middle length,the foreside width and the foreside height of the maxillary were decreased in experimental group（P <0.05）.Conclusion The unilateral cleft alveolar without early intervention plays an important role in maxillary aberration.

Key words: Alveolar Process, Dog, Maxilla, Growth

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