关键词: 静脉畸形, 　局限性血管内凝血, 　D-二聚体, 　纤维蛋白原降解产物

Abstract: Objective　To analysis the clinical features of localized intravascular coagulation (LIC) in patients with venous malformation (VM), so as to attach more importance to such phenomena. Methods　A total of 41 patients with VMs were included in the study, treated in the Department of Burn and Plastic Surgery in Eastern Theater General Hospital from September 1st, 2019 to August 31st, 2020. All of them were examined by MRI and ultrasound to determine the location and area of the lesions. The blood coagulation profile of lesion and circulation was detected after admission to evaluate LIC and the features. The relationships between the abnormal coagulation profile and the lesion number, location, the tissue involved were analyzed. Results　The main manifestations of LIC in VMs were the abnormalities of FIB, FDP, D-dimer and AT3. The incidence of abnormal coagulation indexes of lesion was obviously higher than that of circulation. Multiple, trunk, and craniofacial lesions were more prone to have systemic coagulation abnormalities. There was no significant correlation between the type of tissue involved and the coagulation abnormality in lesion or circulation. Conclusion　The main manifestations of LIC in VMs are the abnormalities of FIB, FDP, D-dimer and AT3. LIC is significantly correlated with the number and location of lesions, but not the types of tissues involved. LIC in the lesion is probably the cause of abnormal systemic coagulation.

Key words: Venous malformation;　Localized intravascular coagulation, 　D-dimer;　Fibrin degradation products