静脉/淋巴管畸形靶向治疗的研究进展

doi:10.3969/j.issn.1673-0364.2020.03.008

摘要/Abstract

摘要：

随着精准医疗概念的提出及脉管畸形遗传学研究领域的突破,靶向药物治疗静脉/淋巴管畸形已成为目前的研究热点。静脉/淋巴管畸形被证实存在体细胞活化突变导致的PI3K/AKT/mTOR通路持续激活,是靶向治疗的基础。本文就靶向药物治疗静脉/淋巴管畸形方面的研究与应用进展进行综述。

关键词: 静脉畸形, 淋巴管畸形, 靶向治疗, 西罗莫司

Abstract: With the introduction of the concept of precision medicine and the breakthrough in the genetics of vascular malformation, developing targeted therapies for low-flow vascular malformation has become a hot spot and urgent task of current research. Low-flow vascular malformation has been confirmed by the presence of somatic activation mutations leading to the continuous activation of the PI3K/AKT/ mTOR pathway, which indicates the possibility of targeted therapies. In this paper, the current researches and applications of targeted drugs in the treatment of low-flow vascular malformation were reviewed.

Key words: Venous malformation, Lymphatic malformation, Targeted therapy, Sirolimus

中图分类号:

R732.2

刘泓源, 葛同鑫, 林晓曦. 静脉/淋巴管畸形靶向治疗的研究进展[J]. 组织工程与重建外科杂志, 2020, 16(3): 204-209.

Hongyuan LIU, Tongxin GE, Xiaoxi LIN. Progress in Targeted Therapy of Low-Flow Vascular Malformation[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020, 16(3): 204-209.

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