组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2023, Vol. 19 ›› Issue (1): 75-.

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软腭发育信号通路的研究进展

  

  • 出版日期:2023-02-01 发布日期:2023-03-08

Research progress of signal pathways in soft palate development 

  • Online:2023-02-01 Published:2023-03-08

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摘要：

腭裂会对言语、吞咽、呼吸和听力产生不利影响。最新研究表明，软腭发育的调控机制可能与硬腭不同。因此，研究参与软腭发育的信号通路是必要的。软腭包括三种细胞类型，即上皮细胞、颅神经嵴来源的间充质细胞、肌源性细胞，这三种细胞间相互作用。本文针对近些年来软腭发育信号通路的研究进展进行综述，以提高对软腭发育调控机制的理解，为改善腭裂的治疗提供依据。

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Abstract:

　Cleft palate can adversely affect speech, swallowing, breathing and hearing. The latest progress in the study of soft
palate development shows that the development of soft palate may be regulated by different pathways related to the development
of hard palate. It is necessary to study the signal pathways involved in the development of soft palate. The soft palate includes
three cell types: epithelial cells, cranial nerve crest-derived mesenchymal cells and muscle-derived cells, which interact with
each other. In this paper, the research progress of soft palate development signal pathway in recent years was reviewed, in order
to improve our understanding of the regulation mechanism of soft palate development, and provide a basis for improving the
treatment of cleft soft palate in the future.

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