皮瓣 , 　缺血再灌注损伤 , 　机制 , 　治疗 , 　纳米酶

　Flap ischemia-reperfusion injury often occurs after skin flap transplantation surgery, which is an important cause

of partial or total necrosis of skin flap. Nowadays, the pathogenesis of flap ischemia-reperfusion injury is not completely clear.

It is generally believed that FIRI is related to the outbreak of reactive oxygen species, the infiltration of neutrophils and the ob

struction of revascularization. Nanozyme is a kind of nano-material with enzyme-like properties, which has the advantages of low

cost, good stability, simple preparation and easy storage. It can directly regulate the redox balance in cells and overcome many

limitations of natural enzyme in enzyme therapy. As an ideal antioxidant, nanozyme will play a vital role in the field of biomed

icine. In this paper, the mechanism of flap ischemia-reperfusion injury and the research and clinical application of treatment

methods in recent years were reviewed, and the application of nanozyme in ischemia-reperfusion injury diseases was introduced,

aiming to provide theoretical basis and new thinking about the treatment of flap ischemia-reperfusion injury.

Skin flap, 　Ischemia-reperfusion injury, 　Mechanism, 　Therapy, 　Nanozymes