关键词: 丛状神经纤维瘤, 　复发, 　队列研究

Abstract: Plexiform neurofibromas （pNF） is an autosomal dominant condition of the nervous system and surgical treatment is the main treatment for pNF. However， it is difficult to remove completely， and postoperative recurrence is common. Based on extensive investigation of domestic and foreign cohort research， the existing factors affecting recurrence of pNF were summarized and analyzed. The recurrence of pNF is mainly related to the location of the primary tumor， the extent of surgical resection， and the age of the patients. Other factors such as tumor growth pattern， depth of invasion， nerve origin， preoperative tumor size， and degree of tumor pain are possible affecting factors for recurrence. At present， there is still a lack of preoperative comprehensive evaluation criteria based on multiple factors， and it is more necessary to rely on the experience of clinicians for surgical judgment. There are some problems in previous studies， such as small sample size， imprecise classification of patients， the factors studied were relatively single， and lack of comprehensive quantitative processing. New clinical cohort studies are needed to provide further evidence support and prognostic evaluation criteria. 

Key words: 　Plexiform neurofibromas, 　Recurrence, 　Cohort study