胶原蛋白基生物材料, 　骨再生修复, 　软骨再生修复, 　交联方式, 　制备工艺

Collagen-based biomaterials can be used as ideal biomaterials for bone and cartilage regeneration and repair due to their good biological activity and biocompatibility. However， due to the weak macroscopic mechanical properties of collagen， which cannot meet the mechanical requirements of natural cartilage and bone tissue， the mechanical properties are often improved by cross-linking modification. In addition， different material forms require different forming technologies. In this paper， the cross-linking methods and forming technologies of collagen-based biomaterials were reviewed， and the construction of collagen scaffolds and the selection of implanted cells for bone and cartilage regeneration and repair in recent years were summarized， aiming to provide clues and ideas for the development of collagen-based biomaterials preparation technology and the transformation of clinical applications.

Collagen-based biomaterials, Bone regeneration and repair, Cartilage regeneration and repair, Crosslinking methods, Forming technologies